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COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA).
Marchesi, Francesco; Salmanton-García, Jon; Emarah, Ziad; Piukovics, Klára; Nucci, Marcio; López-García, Alberto; Rácil, Zdenek; Farina, Francesca; Popova, Marina; Zompi, Sofia; Audisio, Ernesta; Ledoux, Marie-Pierre; Verga, Luisa; Weinbergerová, Barbora; Szotkovski, Tomas; Da Silva, Maria Gomes; Fracchiolla, Nicola; De Jonge, Nick; Collins, Graham; Marchetti, Monia; Magliano, Gabriele; García-Vidal, Carolina; Biernat, Monika M; Van Doesum, Jaap; Machado, Marina; Demirkan, Fatih; Al-Khabori, Murtadha; Zák, Pavel; Vísek, Benjamín; Stoma, Igor; Méndez, Gustavo-Adolfo; Maertens, Johan; Khanna, Nina; Espigado, Ildefonso; Dragonetti, Giulia; Fianchi, Luana; Del Principe, Maria Ilaria; Cabirta, Alba; Ormazabal-Vélez, Irati; Jaksic, Ozren; Buquicchio, Caterina; Bonuomo, Valentina; Batinic, Josip; Omrani, Ali S; Lamure, Sylvain; Finizio, Olimpia; Fernández, Noemí; Falces-Romero, Iker; Blennow, Ola; Bergantim, Rui.
  • Marchesi F; Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome.
  • Salmanton-García J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Res
  • Emarah Z; Oncology Center, Mansoura University, Mansoura.
  • Piukovics K; Department of Internal Medicine, South Division Faculty of Medicine University of Szeged, Szeged.
  • Nucci M; Department of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro.
  • López-García A; Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid.
  • Rácil Z; Institute of Hematology and Blood Transfusion, Prague, Czech Republic Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; IRCCS Ospedale San Raffaele, Milan.
  • Farina F; IRCCS Ospedale San Raffaele, Milan.
  • Popova M; RM Gorbacheva Research Institute, Pavlov University, St. Petersburg.
  • Zompi S; Stem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin.
  • Audisio E; Stem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin.
  • Ledoux MP; ICANS, Strasbourg.
  • Verga L; Azienda Ospedaliera San Gerardo - Monza, Monza, Italy Università Milano-Bicocca, Milan.
  • Weinbergerová B; University Hospital Brno - Department of Internal Medicine, Hematology and Oncology, Brno, Czech Republic.
  • Szotkovski T; University Hospital Olomouc, Olomouc, Czech Republic.
  • Da Silva MG; Portuguese Institute of Oncology, Lisbon.
  • Fracchiolla N; Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
  • De Jonge N; Amsterdam UMC, location VUmc, Amsterdam.
  • Collins G; Oxford University Hospitals, Oxford.
  • Marchetti M; Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria.
  • Magliano G; ASST Grande Ospedale Metropolitano Niguarda, Milan.
  • García-Vidal C; Department of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, Barcelona.
  • Biernat MM; Department of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw.
  • Van Doesum J; University Medical Center Groningen, Groningen.
  • Machado M; Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid.
  • Demirkan F; Dokuz Eylul University, Division of Hematology, Izmir.
  • Al-Khabori M; Sultan Qaboos University Hospital, Muscat.
  • Zák P; University Hospital Hradec Králové, Hradec Králové, Czech Republic.
  • Vísek B; University Hospital Hradec Králové, Hradec Králové, Czech Republic.
  • Stoma I; Gomel State Medical University, Gomel.
  • Méndez GA; Hospital Escuela de Agudos Dr. Ramón Madariaga, Posadas.
  • Maertens J; Department of Microbiology, Immunology, and Transplantation, KULeuven, Leuven and Department of Hematology, UZ Leuven, Leuven.
  • Khanna N; Division of Infectious Diseases and Hospital Epidemiology, and Department of Clinical Research, University and University Hospital of Basel, Basel.
  • Espigado I; Department of Hematology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS / CSIC), Universidad de Sevilla (Departamento de Medicina), Seville.
  • Dragonetti G; Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome.
  • Fianchi L; Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome.
  • Del Principe MI; Hematology Unit, Department of Biomedicine and Prevention, Tor Vergata University of Rome.
  • Cabirta A; Department of Hematology, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra.
  • Ormazabal-Vélez I; Complejo Hospitalario de Navarra, Iruña-Pamplona.
  • Jaksic O; University Hospital Dubrava, Zagreb, Croatia.
  • Buquicchio C; Ematologia con Trapianto, Ospedale Dimiccoli Barletta, Barletta.
  • Bonuomo V; Department of Medicine, Section of Hematology, University of Verona, Verona.
  • Batinic J; University Hospital Centre Zagreb, Zagreb, Croatia Croatian Cooperative Group for Hematological Diseases (CROHEM), Croatia Faculty of Medicine University of Zagreb, Zagreb, Croatia.
  • Omrani AS; Hamad Medical Corporation, Division of Infectious Diseases, Doha.
  • Lamure S; Département d'Hématologie Clinique, CHU de Montpellier, UMR-CNRS 5535, Universite de Montpellier, Montpellier.
  • Finizio O; UOC Hematology, AORN Cardarelli, Naples.
  • Fernández N; Hospital Universitario Marqués de Valdecilla, Santander.
  • Falces-Romero I; La Paz University Hospital, Madrid.
  • Blennow O; Department of Infectious Diseases, Karolinska University Hospital, Stockholm.
  • Bergantim R; Centro Hospitalar e Universitário São João, Porto.
Haematologica ; 2022 May 12.
Article in English | MEDLINE | ID: covidwho-1841291
ABSTRACT
Patients with acute myeloid leukemia (AML) are at high risk of mortality from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients with COVID-19 diagnosis between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the prior 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with an improved survival when AML treatment could be delayed (80%; p.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Risk factors Topics: Long Covid Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Risk factors Topics: Long Covid Language: English Year: 2022 Document Type: Article