Current advance of basic and clinical medical virology
Journal of Shandong University
; 59(5):15-21, 2021.
Article
in Chinese
| GIM | ID: covidwho-1841670
ABSTRACT
Coronavirus disease 2019 (COVID-19), which is caused by a novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become the worst pandemic and public health crisis across the globe once a century. This pandemic has caused huge losses in both human lives and global economy. Innate immunity is the first line of defense against pathogenic invasions. Extensive studies by scientists in China and the world have reported that SARS-CoV-2 can employ multiple strategies to evade host innate immunity, and such immune evasion mechanisms have become critical contributing factors for the pathogenicity of SARS-CoV-2. On the other hand, the pathogenesis of COVID-19 has been found to be closely relevant with the pro-inflammatory responses induced by SARS-CoV-2 infection in humans. This paper provides a brief review to the relationship between SARS-CoV-2 infection and innate immunity as well as inflammation.
pathogenesis; human diseases; coronavirus disease 2019; immunity; immune response; viral diseases; pandemics; immune evasion; infectious diseases; inflammation; pathogenicity; public health; Severe acute respiratory syndrome coronavirus 2; man; China; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; APEC countries; East Asia; Asia; high Human Development Index countries; upper-middle income countries; SARS-CoV-2; immunity reactions; immunological reactions; viral infections; People's Republic of China; communicable diseases
Full text:
Available
Collection:
Databases of international organizations
Database:
GIM
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Shandong University
Year:
2021
Document Type:
Article
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