Assessment of coagulopathy, inflammation and LDH activity in SARS-CoV-2-infected patients
Texila International Journal of Public Health
; 9(3), 2021.
Article
in English
| GIM | ID: covidwho-1841769
ABSTRACT
The patho-physiology of COVID19 is still not clear. This study investigated the status of coagulation, LDH activity, and inflammation in SARS-CoV-2 infected patients. One hundred and thirty-four newly diagnosed COVID19 infected patients (age ranged 65-82 years) attending Mullingar Regional Hospital, Mullingar, Republic of Ireland, volunteered to participate in this study. They all presented with a pulmonary disorder, pyrexia, vomiting, body pains, etc. SARS-CoV-2 confirmatory test was done with RT-PCR molecular test using Cepheid Genexpert System. The data of another 121 plasma samples of apparently normal, non-COVID19 infected individuals taken before the emergence of COVID19 served as controls. Levels of blood platelets was determined in the participants using Siemen ADVIA 2120 Haematological System, and plasma D-dimer was determined in the participants using Star Max-Stago-Automatic Coagulation Analyzer LDH activity, plasma ferritin, and C-reactive protein (CRP) were determined in the participants using Beckman AU680-Chemistry Analyser. SARS-CoV-2 -infected patients showed significantly (p< 0.001) higher levels of D-dimer (1522.95+1395.45 ng/ml), CRP (125.3+116.4 mg/l), ferritin (488.5+514.9pg/l), and LDH activity (574.4+446.7iu/l) compared to controls (78.8+18.1 ng/ml, 2.4+1.7 mg/l, 61.3+58.2pg/l, 304.1+76.6iu/l respectively). The blood platelet count did not show significant (p>0.05) change in the COVID19 patients (252.2 x 109+101 x 109) compared to controls (256.4 x 109+63.2 x 109). Elevated LDH activity could indicate tissue breakdown in the SARS-Cov-2 infected patients. Hyper-coagulation and inflammation are imminent in the COVID19 patients. Adjuvant anticoagulant and anti-inflammatory therapies may be useful as part of therapeutic regimen in the SARS-CoV-2 infected patients.
9007-41-4; 9007-73-2; 9001-60-9; coronavirus disease 2019; human diseases; viral diseases; blood plasma; adjuvants; anticoagulants; C-reactive protein; diagnostic techniques; ferritin; fever; haematology; inflammation; lungs; platelet count; platelets; lactate dehydrogenase; Severe acute respiratory syndrome coronavirus 2; man; Irish Republic; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; British Isles; Western Europe; Europe; European Union Countries; high income countries; OECD Countries; very high Human Development Index countries; SARS-CoV-2; viral infections; plasma (blood); pyrexia; hematology; blood platelets; thrombocytes; Eire
Full text:
Available
Collection:
Databases of international organizations
Database:
GIM
Language:
English
Journal:
Texila International Journal of Public Health
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS