Association of tumor necrosis factor alpha ‐308 single nucleotide polymorphism with SARS CoV‐2 infection in an Iraqi Kurdish population
Journal of Clinical Laboratory Analysis
; 36(5), 2022.
Article
in English
| ProQuest Central | ID: covidwho-1842603
ABSTRACT
Uncovering risk factors playing roles in the severity of Coronavirus disease 2019 (Covid‐19) are important for understanding pathoimmunology of the disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS CoV‐2). Genetic variations in innate immune genes have been found to be associated with Covid‐19 infections. A single‐nucleotide polymorphism (SNP) in a promoter region of tumor necrosis factor alpha (TNF‐α) gene, TNF‐α −308G>A, increases expression of TNF‐α protein against infectious diseases leading to immune dysregulations and organ damage. This study aims to discover associations between TNF‐α −308G>A SNP and Covid‐19 infection. Polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) was used for genotyping a general Kurdish population and Covid‐19 patients. The homozygous mutant (AA) genotype was found to be rare in the current studied population. Interestingly, the heterozygous (GA) genotype was significantly (p value = 0.0342) higher in the Covid‐19 patients than the general population. This suggests that TNF‐α −308G>A SNP might be associated with Covid‐19 infections. Further studies with larger sample sizes focusing on different ethnic populations are recommended.
Medical Sciences--Experimental Medicine, Laboratory Technique; Covid‐19; Iraq; polymorphism; SARS CoV‐2; SNP; TNF‐ 308; Coronaviruses; Genotyping; Gene polymorphism; Infectious diseases; Restriction fragment length polymorphism; Risk factors; Severe acute respiratory syndrome coronavirus 2; Tumor necrosis factor-TNF; Polymerase chain reaction; Single-nucleotide polymorphism; COVID-19; Gene loci; Tumor necrosis factor-α; Population studies; Genetic diversity; Kurdistan
Search on Google
Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Journal of Clinical Laboratory Analysis
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS