Clinical features, laboratory characteristics and risk factors for mortality of COVID-19 patients in a secondary hospital in Oman during the first wave of the SARS-CoV-2 pandemic
Bulletin of the National Research Centre
; 46(1), 2022.
Article
in English
| ProQuest Central | ID: covidwho-1842610
ABSTRACT
BackgroundThe changing epidemiological profile of the COVID-19 pandemic and the uncertain clinical picture of patients characterise this ongoing and most challenging health event.ObjectivesTo report clinical features, laboratory characteristics, and mortality risk factors among COVID-19 patients admitted to a secondary hospital in Oman.MethodsA retrospective study for the first 455 patients admitted with COVID-19 to Rustaq hospital from 12th April, 2020 to 27th September, 2020. A predesigned questionnaire collected data from the hospital medical electronic system.ResultsThe mean age was 42.84 (SD = 19.86) years, and the majority of patients were aged 30 to 59 and 60 or above;207 (45.5%) and 189 (41.5%), respectively. Male patients constituted approximately two-thirds of the subjects. Fever, dyspnea and cough were the most common presenting symptoms (69%, 66%, and 62%, respectively), while comorbidities with diabetes mellitus and hypertension were 47% and 44%, respectively. Bacterial growth was identified at approximately 10%. Bivariate analysis turned out to be significant with a number of factors. However, multivariate analysis showed significance with patients aged over 60 (OR = 7.15, 95% CI 1.99–25.63), dyspnea (OR = 2.83, 95% CI 1.5–5.33), dyslipidemia (OR = 1.93, 95% CI 1.02–3.66) and being bed-ridden (OR = 5.01, 95% CI 1.73–14.44). Durations from onset of symptoms to admission and respiratory distress were lower among patients who died;p = 0.024 and p = 0.001, respectively. Urea, Troponin and LDH may act as potential diagnostic biomarkers for severity or mortality.ConclusionsThis study identified groups of patients with a higher risk of mortality, with severe disturbance in the laboratory markers while some could act as potential diagnostic biomarkers.
Sciences: Comprehensive Works; COVID19; Oman; Mortality; Clinical characteristics; Laboratory; Risk factors; SARS CoV-2; Pandemics; Laboratories; Respiration; Electronic systems; Epidemiology; Severe acute respiratory syndrome coronavirus 2; Dyspnea; Hypertension; Multivariate analysis; COVID-19; Viral diseases; Risk analysis; Urea; Fever; Calcium-binding protein; Cough; Diabetes mellitus; Biomarkers; Troponin; Dyslipidemia; Diagnostic systems; Patients; Coronaviruses; Bivariate analysis
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Collection:
Databases of international organizations
Database:
ProQuest Central
Type of study:
Prognostic study
Language:
English
Journal:
Bulletin of the National Research Centre
Year:
2022
Document Type:
Article
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