Protocol for the economic evaluation of COVID-19 pandemic response policies
BMJ Open
; 11(9), 2021.
Article
in English
| ProQuest Central | ID: covidwho-1842675
ABSTRACT
IntroductionSeveral treatment options are available for COVID-19 to date. However, the use of a combination of non-pharmaceutical interventions (NPIs) is necessary for jurisdictions to contain its spread. Although the implementation cost of NPIs may be low from the healthcare system perspective, it can be costly when considering the indirect costs from the societal perspective. COVID-19 vaccination campaigns have begun in several countries worldwide. Nonetheless, the quantity of vaccines available remain limited over the next 1 to 2 years. A tool for informing vaccine prioritisation that considers both cost and effectiveness will be highly useful. This study aims to identify the most cost-effective combination of COVID-19 response policies, using Singapore as an example.Methods and analysisAn age-stratified Susceptible-Exposed-Infectious-Recovered model will be used to generate the number of infections stratified by disease severity under different intervention scenarios. Polices of interest include test-trace-isolate, travel restriction, compulsory face mask and hygiene practices, social distancing, dexamethasone/remdesivir therapy and vaccination. The latest phase 3 trial results and the WHO Target Product Profiles for COVID-19 vaccines will be used to model vaccine characteristics. A cost (expected resource utilisation and productivity losses) and quality-adjusted life years (QALYs) will be attached to these outputs for a cost-utility analysis. The primary outcome measure will be the incremental cost-effectiveness ratio generated from the incremental cost of policy alternatives expressed as a ratio of the incremental benefits (QALYs gained). Efficacy of policy options will be gathered from literature review and from its observed impacts in Singapore. Cost data will be gathered from healthcare institutions, Ministry of Health and published data. Sensitivity analysis such as threshold analysis and scenario analysis will be conducted.Ethics and disseminationEthics approval was not required for this study. The study findings will be disseminated through peer-reviewed journals.
Medical Sciences; COVID-19; health economics; health services administration & management; public health; Chicken pox; Infections; Infectious diseases; Social distancing; COVID-19 vaccines; Severe acute respiratory syndrome coronavirus 2; Pharmaceuticals; Pandemics; Decision making; Influenza; Cost analysis; Jurisdiction; Probability; Age groups; Gross Domestic Product--GDP; Health care industry; Viral infections; Coronaviruses; Immunization; Disease transmission; Singapore; United States--US
Search on Google
Collection:
Databases of international organizations
Database:
ProQuest Central
Type of study:
Experimental Studies
Language:
English
Journal:
BMJ Open
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS