Liver Steatosis: A Marker of Metabolic Risk in Children
International Journal of Molecular Sciences
; 23(9):4822, 2022.
Article
in English
| ProQuest Central | ID: covidwho-1842716
ABSTRACT
Obesity is one of the greatest health challenges affecting children of all ages and ethnicities. Almost 19% of children and adolescents worldwide are overweight or obese, with an upward trend in the last decades. These reports imply an increased risk of fat accumulation in hepatic cells leading to a series of histological hepatic damages gathered under the acronym NAFLD (Non-Alcoholic Fatty Liver Disease). Due to the complex dynamics underlying this condition, it has been recently renamed as ‘Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)’, supporting the hypothesis that hepatic steatosis is a key component of the large group of clinical and laboratory abnormalities of Metabolic Syndrome (MetS). This review aims to share the latest scientific knowledge on MAFLD in children in an attempt to offer novel insights into the complex dynamics underlying this condition, focusing on the novel molecular aspects. Although there is still no treatment with a proven efficacy for this condition, starting from the molecular basis of the disease, MAFLD’s therapeutic landscape is rapidly expanding, and different medications seem to act as modifiers of liver steatosis, inflammation, and fibrosis.
Chemistry--Organic Chemistry; NAFLD and children; NASH and children; pediatric MAFLD; Metabolic Syndrome (MetS) and children; hepatic fibrosis in children; Population; Severe acute respiratory syndrome coronavirus 2; Epidemiology; Fatty liver; Risk factors; Disease prevention; Liver diseases; Ethnicity; Metabolic disorders; Pediatrics; Body weight; COVID-19; Children; Abnormalities; African Americans; Spectrum analysis; Pandemics; Obesity; Health risk assessment; Overweight; Metabolic syndrome; Hispanic people; Steatosis; Liver; Pathogenesis; Fibrosis; Teenagers
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Collection:
Databases of international organizations
Database:
ProQuest Central
Type of study:
Prognostic study
Language:
English
Journal:
International Journal of Molecular Sciences
Year:
2022
Document Type:
Article
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