Neurological manifestations in patients with COVID‐19: A systematic review and meta‐analysis
Journal of Clinical Laboratory Analysis
; 36(5), 2022.
Article
in English
| ProQuest Central | ID: covidwho-1842968
ABSTRACT
IntroductionThe intensification of coronavirus disease 2019 (COVID‐19) complications, severe symptoms, and high mortality rate has led researchers to focus on this significant issue. While respiratory and cardiac complications have been described as high‐risk manifestations in patients with COVID‐19, neurological complications can also enhance mortality. This study aimed to evaluate the prevalence of neurological complications arises from SARS‐CoV‐2 and assess the mortality rate from neurological complications.Material and MethodsLiterature review was conducted by searching in PubMed/Medline, Web of Sciences, and Embase. After performing search strategies with relevant terms, a number of articles were excluded, including review articles, systematic review or meta‐analysis, duplicate publication of same researchers, congress s, animal studies, case reports, case series, and articles reporting a history of neurological features prior to COVID‐19 infection. After retrieving the data, statistical analysis was performed using the STATA Version 14 software.ResultsFrom 4455 retrieved publications, 20 articles were selected for further analysis. Among 18,258 included patients, 2791 showed neurological symptoms, which were classified into different groups. Headache, confusion, and fatigue were reported as the most non‐specific neurological features in confirmed COVID‐19 patients. Psychiatric symptoms, CNS disorders, cerebrovascular disorders, CNS inflammatory disorders, PNS disorders, neuromuscular disorders, etc., were defined as specific neurological manifestations. The pooled prevalence of neurological manifestations and mortality rate of COVID‐19 patients with neurological features were estimated to be 23.0% (95% CI 17.8–29.2) and 29.1% (95% CI 20.3–39.8), respectively.ConclusionNeurological manifestations may commonly happen in patients with COVID‐19. This study reported a high prevalence of neurological complications and mortality rates in COVID‐19 patients. Therefore, patients with COVID‐19 who indicated neurological symptoms should be taken seriously and should receive early treatment to prevent undesirable events.
Medical Sciences--Experimental Medicine, Laboratory Technique; COVID‐19; nervous system; neurological manifestations; SARS‐CoV‐2; Neurological complications; Severe acute respiratory syndrome coronavirus 2; Mortality; Anesthesia; Delirium; Neuromuscular diseases; COVID-19; Statistical analysis; Medical imaging; Inflammatory diseases; Visual impairment; Coronaviruses; Case reports; Cerebrovascular diseases; Stroke; Encephalitis; Pneumonia; Literature reviews; Coma; Middle East respiratory syndrome; Headaches; Viruses; Meta-analysis; Consciousness; Vertigo; Patients; Systematic review; Movement disorders; Turkey; United States--US; China; Italy; France
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Collection:
Databases of international organizations
Database:
ProQuest Central
Type of study:
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
Journal of Clinical Laboratory Analysis
Year:
2022
Document Type:
Article
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