Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
Molecules
; 27(9):2939, 2022.
Article
in English
| ProQuest Central | ID: covidwho-1843148
ABSTRACT
Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon–sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3H)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32–99%).
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Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Molecules
Year:
2022
Document Type:
Article
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