New-onset and relapse of nephrotic syndrome following COVID-19 vaccination: a questionnaire survey in Japan.
Clin Exp Nephrol
; 26(9): 909-916, 2022 Sep.
Article
in English
| MEDLINE | ID: covidwho-1844393
ABSTRACT
BACKGROUND:
Recent clinical reports indicate a correlation between new-onset and relapse of nephrotic syndrome (NS) following coronavirus 2019 (COVID-19) vaccination in patients with glomerular diseases. However, there are no reports of a nationwide survey on NS following COVID-19 vaccination in Japan.METHODS:
We conducted a web-based survey of council members of the Japanese Society of Nephrology (581 members, 382 facilities) to elucidate the relationship between COVID-19 vaccination and new-onset and relapse of NS.RESULTS:
Following COVID-19 vaccination, 27 patients (male 15, 55.6%) with new-onset (n = 6) and relapse (n = 21) of NS were reported. Of them, 12 (44.4%) patients were diagnosed with minimal change disease at the occurrence of NS. Five patients developed a slight increase in serum creatinine levels; however, none progressed to severe renal dysfunction.CONCLUSION:
Our findings clarify the clinical features of new-onset and relapse of NS following COVID-19 vaccination. Although there was no obvious progression to severe renal dysfunction, clinicians and pathologists should be aware that NS is a potential adverse effect of the vaccines.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19 Vaccines
/
COVID-19
/
Nephrotic Syndrome
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Clin Exp Nephrol
Journal subject:
Nephrology
Year:
2022
Document Type:
Article
Affiliation country:
S10157-022-02231-y
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