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Convalescent serum-derived exosomes: Attractive niche as COVID-19 diagnostic tool and vehicle for mRNA delivery.
Krishnan, Anand; Gangadaran, Prakash; Chavda, Vivek P; Jogalekar, Manasi P; Muthusamy, Ramesh; Valu, Disha; Vadivalagan, Chithravel; Ramani, Prasanna; Laishevtcev, Alexey; Katari, Naresh Kumar; Ahn, Byeong-Cheol.
  • Krishnan A; Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South Africa.
  • Gangadaran P; Department of Chemical Pathology, School of Pathology, National Health Laboratory Services, Bloemfontein 9301, South Africa.
  • Chavda VP; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Jogalekar MP; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Republic of Korea.
  • Muthusamy R; Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad 380009, India.
  • Valu D; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA.
  • Vadivalagan C; Department of Pharmaceutical Analysis, Omega College of Pharmacy, Hyderabad 501301, India.
  • Ramani P; Research and Development, Intas Pharmaceuticals Ltd. (Biopharma Division), Ahmedabad 382213, India.
  • Laishevtcev A; Molecular Cell Physiology Laboratory, Department of Biochemistry, School of Medicine, AKFA University, Tashkent 100042, Uzbekistan.
  • Katari NK; Dhanvanthri Lab, Department of Sciences, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore 641112, India.
  • Ahn BC; Center of Excellence in Advanced Materials & Green Technologies (CoE-AMGT), Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore 641112, India.
Exp Biol Med (Maywood) ; 247(14): 1244-1252, 2022 07.
Article in English | MEDLINE | ID: covidwho-1846736
ABSTRACT
The spread of SARS-CoV-2 over the entire world is more commonly known as COVID-19. COVID-19 has impacted society in every aspect of routine life. SARS-CoV-2 infection is often misdiagnosed as influenza or seasonal upper respiratory tract viral infections. General diagnostic tools can detect the viral antigen or isotypes of antibodies. However, inter- and intraindividual variations in antibody levels can cause false negatives in antibody immunoassays. On the contrary, the false-positive test results can also occur due to either cross-reactivity of the viral antigens or some other patient-related autoimmune factors. There is need for a cogent diagnostic tool with more specificity, selectivity, and reliability. Here, we have described the potential of convalescent serum-derived exosome as a diagnostic tool for the detection of SARS-CoV-2, even in asymptomatic patients, which is a limitation for currently practiced diagnostic tests throughout the globe. In addition, its potential as a vehicle for messenger RNA (mRNA) delivery is also emphasized.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Exosomes / COVID-19 Type of study: Diagnostic study / Randomized controlled trials Limits: Humans Language: English Journal: Exp Biol Med (Maywood) Journal subject: Biology / Physiology / Medicine Year: 2022 Document Type: Article Affiliation country: 15353702221092984

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Exosomes / COVID-19 Type of study: Diagnostic study / Randomized controlled trials Limits: Humans Language: English Journal: Exp Biol Med (Maywood) Journal subject: Biology / Physiology / Medicine Year: 2022 Document Type: Article Affiliation country: 15353702221092984