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MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine.
Boulouis, Caroline; Kammann, Tobias; Cuapio, Angelica; Parrot, Tiphaine; Gao, Yu; Mouchtaridi, Elli; Wullimann, David; Lange, Joshua; Chen, Puran; Akber, Mira; Rivera Ballesteros, Olga; Muvva, Jagadeeswara Rao; Smith, C I Edvard; Vesterbacka, Jan; Kieri, Oscar; Nowak, Piotr; Bergman, Peter; Buggert, Marcus; Ljunggren, Hans-Gustaf; Aleman, Soo; Sandberg, Johan K.
  • Boulouis C; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Kammann T; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Cuapio A; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Parrot T; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Gao Y; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Mouchtaridi E; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Wullimann D; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Lange J; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Chen P; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Akber M; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Rivera Ballesteros O; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Muvva JR; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 14152, Stockholm, Sweden.
  • Smith CIE; Department of Laboratory Medicine, Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden.
  • Vesterbacka J; Department of Laboratory Medicine, Translational Research Center Karolinska (TRACK), Karolinska Institutet, Stockholm, Sweden.
  • Kieri O; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
  • Nowak P; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.
  • Bergman P; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
  • Buggert M; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.
  • Ljunggren HG; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
  • Aleman S; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.
  • Sandberg JK; Department of Laboratory Medicine, Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden.
Mol Med ; 28(1): 54, 2022 05 13.
Article in English | MEDLINE | ID: covidwho-1846787
ABSTRACT
Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like capacity to rapidly respond to microbial infection via MR1-restricted antigen recognition. Emerging evidence indicate that they can also act as rapid sensors of viral infection via innate cytokine activation. However, their possible role in the immune response to mRNA vaccination is unknown. Here, we evaluated the involvement of MAIT cells in individuals vaccinated with the BNT162b2 mRNA SARS-CoV-2 vaccine. MAIT cell levels, phenotype and function in circulation were preserved and unperturbed through day 35 post-vaccination in healthy donor (HD) vaccinees, as well as people living with HIV (PLWH) or with primary immunodeficiency (PID). Unexpectedly, pre-vaccination and post-vaccination levels of MAIT cells correlated positively with the magnitude of the SARS-CoV-2 spike protein-specific CD4 T cell and antibody responses in the HD vaccinees. This pattern was largely preserved in the PID group, but less so in the PLWH group. Furthermore, in the HD vaccinees levels of MAIT cell activation and cytolytic potential correlated negatively to the adaptive antigen-specific immune responses. These findings indicate an unexpected association between MAIT cell compartment characteristics and the immune response magnitude to the BNT162b2 mRNA vaccine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mucosal-Associated Invariant T Cells / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Mol Med Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: S10020-022-00484-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mucosal-Associated Invariant T Cells / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Mol Med Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: S10020-022-00484-7