Your browser doesn't support javascript.
Addition of digital VIA/VILI to conventional naked-eye examination for triage of HPV-positive women: A study conducted in a low-resource setting.
Dufeil, Eva; Kenfack, Bruno; Tincho, Evelyn; Fouogue, Jovanny; Wisniak, Ania; Sormani, Jessica; Vassilakos, Pierre; Petignat, Patrick.
  • Dufeil E; Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Kenfack B; Faculty of Medicine and Pharmaceutical Science, University of Dschang, Dschang, Cameroon.
  • Tincho E; Department of Gynecology and Obstetrics, District Hospital of Dschang, Dschang, Cameroon.
  • Fouogue J; Faculty of Medicine and Pharmaceutical Science, University of Dschang, Dschang, Cameroon.
  • Wisniak A; Department of Gynecology and Obstetrics, Faculty of Medicine and Biomedical Sciences, Centre Hospitalier Universitaire (CHUY), Yaoundé, Cameroon.
  • Sormani J; Department of Obstetrics and Gynecology, Bafoussam Regional hospital, Bafoussam, Cameroon.
  • Vassilakos P; Gynecology Division, Department of Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
  • Petignat P; Population Epidemiology Unit, Department of Primary Care, Geneva University Hospitals, Geneva, Switzerland.
PLoS One ; 17(5): e0268015, 2022.
Article in English | MEDLINE | ID: covidwho-1846932
ABSTRACT

BACKGROUND:

World Health Organization guidelines for cervical cancer screening recommend HPV testing followed by visual inspection with acetic acid (VIA) for triage if HPV positive. In order to improve visual assessment and identification of cervical intraepithelial neoplasia grade 2 and worse (CIN2+), providers may use visual aids such as digital cameras.

OBJECTIVES:

To determine whether combined examination by naked-eye and digital VIA (D-VIA) and VILI (D-VILI) improves detection of CIN2+ as compared to the conventional evaluation. MATERIALS AND

METHODS:

Women (30-49 years) living in Dschang (West Cameroon) were prospectively invited to a cervical cancer screening campaign. Primary HPV-based screening was followed by VIA/VILI and D-VIA/VILI if HPV-positive. Health care providers independently defined diagnosis (pathological or non-pathological) based on naked-eye VIA/VILI and D-VIA/VILI. Decision to treat was based on combined examination (VIA/VILI and D-VIA/VILI). Cervical biopsy and endocervical curettage were performed in all HPV-positive participants and considered as reference standard. Diagnostic performance of individual and combined naked-eye VIA/VILI and D-VIA/VILI was evaluated. A sample size of 1,500 women was calculated assuming a prevalence of 20% HPV positivity and 10% CIN2+ in HPV-positive women.

RESULTS:

Due to the COVID-19 pandemic, the study had to terminate prematurely. A total of 1,081 women with a median age of 40 (IQR 35.5-45) were recruited. HPV positivity was 17.4% (n = 188) and 26 (14.4%) had CIN2+. Naked-eye VIA and D-VIA sensitivities were 80.8% (95% CI 60.6-93.4) and 92.0% (95% CI 74.0-99.0), and specificities were 31.2% (95% CI 24-39.1) and 31.6% (95% CI 24.4-39.6), respectively. The combination of both methods yielded a sensitivity of 92.3% (95% CI 74.9-99.1) and specificity of 23.2% (95% CI 16.8-30.7). A trend towards improved sensitivity was observed, but did not reach statistical significance.

CONCLUSION:

Addition of D-VIA/VILI to conventional naked-eye examination may be associated with improved CIN2+ identification. Further studies including a larger sample size are needed to confirm these results.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Papillomavirus Infections / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study Limits: Female / Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0268015

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Papillomavirus Infections / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study Limits: Female / Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0268015