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Analysis of the Protective Efficacy of Approved COVID-19 Vaccines Against Various Mutants.
Li, Chaonan; Guo, Yikai; Fang, Zhongbiao; Zhang, Haiyan; Zhang, Yanjun; Chen, Keda.
  • Li C; Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
  • Guo Y; Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
  • Fang Z; Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
  • Zhang H; Zhejiang Shuren College, Zhejiang Chinese Medical University, Hangzhou, China.
  • Zhang Y; Department of Virus Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
  • Chen K; Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
Front Immunol ; 13: 804945, 2022.
Article in English | MEDLINE | ID: covidwho-1847170
ABSTRACT
The outbreak of COVID-19 (caused by SARS-CoV-2) has posed a significant threat to global public health security because of its high pathogenicity and infectivity. To date, the pathogenic mechanism of this novel coronavirus (SARS-CoV-2) is still unclear, and there is no effective treatment. As one of the most effective strategies to prevent viral infection, vaccines have become a research hotspot. Based on the current understanding of SARS-CoV-2, the research and development of its vaccines cover almost all forms of current vaccine research, including inactivated vaccines, recombinant protein vaccines, viral vector vaccines, and nucleic acid vaccines. Moreover, with the spread of the new mutant virus, it is necessary to evaluate the protection rate of previous administered vaccines. This article reviews the candidate targets, vaccine types, research and development status, progress of SARS-CoV-2 vaccines, and the effectiveness of neutralizing antibodies against SARS-CoV-2 mutants (B.1.1.7, B.1.351, P.1, B.1.617.2, and B.1.1.529) induced by these vaccines, to provide a reference for follow-up research and prevention.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Type of study: Cohort study / Experimental Studies / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.804945

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Type of study: Cohort study / Experimental Studies / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.804945