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The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in Mice.
Zhang, Cheng; Cui, Huan; Li, Entao; Guo, Zhendong; Wang, Tiecheng; Yan, Fang; Liu, Lina; Li, Yuanguo; Chen, Di; Meng, Keyin; Li, Nan; Qin, Chengfeng; Liu, Juxiang; Gao, Yuwei; Zhang, Chunmao.
  • Zhang C; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Cui H; College of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
  • Li E; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Guo Z; College of Veterinary Medicine, Jilin University, Changchun, China.
  • Wang T; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Yan F; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Liu L; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Li Y; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Chen D; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Meng K; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Li N; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Qin C; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Liu J; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Gao Y; Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Zhang C; College of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
Front Immunol ; 13: 869809, 2022.
Article in English | MEDLINE | ID: covidwho-1847173
ABSTRACT
Previous studies have shown that B.1.351 and other variants have extended the host range of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to mice. Sustained transmission is a prerequisite for viral maintenance in a population. However, no evidence of natural transmission of SARS-CoV-2 in wild mice has been documented to date. Here, we evaluated the replication and contact transmission of the B.1.351 variant in mice and rats. The B.1.351 variant could infect and replicate efficiently in the airways of mice and rats. Furthermore, the B.1.351 variant could not be transmitted in BALB/c or C57BL/6 mice but could be transmitted with moderate efficiency in rats by direct contact. Additionally, the B.1.351 variant did not transmit from inoculated Syrian hamsters to BALB/c mice. Moreover, the mouse-adapted SARS-CoV-2 strain C57MA14 did not transmit in mice. In summary, the risk of B.1.351 variant transmission in mice is extremely low, but the transmission risk in rats should not be neglected. We should pay more attention to the potential natural transmission of SARS-CoV-2 variants in rats and their possible spillback to humans.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Variants Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.869809

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Variants Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.869809