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Association between the Right Ventricular Longitudinal Shortening Fraction and Mortality in Acute Respiratory Distress Syndrome Related to COVID-19 Infection: A Prospective Study.
Beyls, Christophe; Daumin, Camille; Hermida, Alexis; Booz, Thomas; Ghesquieres, Tristan; Crombet, Maxime; Martin, Nicolas; Huette, Pierre; Jounieaux, Vincent; Dupont, Hervé; Abou-Arab, Osama; Mahjoub, Yazine.
  • Beyls C; Department of Anesthesiology and Critical Care Medicine, Amiens University Hospital, F-80054 Amiens, France.
  • Daumin C; UR UPJV 7518 SSPC (Simplification of Care of Complex Surgical Patients) Research Unit, University of Picardie Jules Verne, F-80000 Amiens, France.
  • Hermida A; Department of Anesthesiology and Critical Care Medicine, Amiens University Hospital, F-80054 Amiens, France.
  • Booz T; Department of Cardiology, Amiens University Hospital, F-80054 Amiens, France.
  • Ghesquieres T; Department of Anesthesiology and Critical Care Medicine, Amiens University Hospital, F-80054 Amiens, France.
  • Crombet M; Department of Anesthesiology and Critical Care Medicine, Amiens University Hospital, F-80054 Amiens, France.
  • Martin N; Department of Anesthesiology and Critical Care Medicine, Amiens University Hospital, F-80054 Amiens, France.
  • Huette P; Department of Cardiology, Amiens University Hospital, F-80054 Amiens, France.
  • Jounieaux V; Department of Anesthesiology and Critical Care Medicine, Amiens University Hospital, F-80054 Amiens, France.
  • Dupont H; UR UPJV 7518 SSPC (Simplification of Care of Complex Surgical Patients) Research Unit, University of Picardie Jules Verne, F-80000 Amiens, France.
  • Abou-Arab O; Respiratory Department, Amiens University Hospital, F-80054 Amiens, France.
  • Mahjoub Y; Department of Anesthesiology and Critical Care Medicine, Amiens University Hospital, F-80054 Amiens, France.
J Clin Med ; 11(9)2022 May 06.
Article in English | MEDLINE | ID: covidwho-1847356
ABSTRACT

INTRODUCTION:

Right ventricular systolic dysfunction (RVsD) increases acute respiratory distress syndrome mortality in COVID-19 infection (CARDS). The RV longitudinal shortening fraction (RV-LSF) is an angle-independent and automatically calculated speckle-tracking parameter. We explored the association between RV-LSF and 30-day mortality in CARDS patients.

METHODS:

Moderate-to-severe CARDS patients hospitalized at Amiens University Hospital with transesophageal echocardiography performed within 48 h of intensive care unit admission were included. RVsD was defined by an RV-LSF of <20%. The patients were divided into two groups according to the presence of RVsD. Using multivariate Cox regression, clinical and echocardiographic risk factors predicting 30-day mortality were evaluated.

RESULTS:

Between 28 February 2020 and 1 December 2021, 86 patients were included. A total of 43% (n = 37/86) of the patients showed RVsD and 22% (n = 19/86) of the patients died. RV-LSF was observed in 26 (23.1-29.7)% of the no-RVsD function group and 16.5 (13.7-19.4)% (p < 0.001) of the RVsD group. Cardiogenic shock (n = 7/37 vs. 2/49, p = 0.03) and acute cor pulmonale (n = 18/37 vs. 10/49, p = 0.009) were more frequent in the RVsD group. The 30-day mortality was higher in the RVsD group (15/37 vs. 4/49, p = 0.001). In a multivariable Cox model, RV-LSF was an independent mortality factor (HR 4.45, 95%CI (1.43-13.8), p = 0.01).

CONCLUSION:

in a cohort of moderate-to-severe CARDS patients under mechanical ventilation, RVsD defined by the RV-LSF was associated with higher 30-day mortalities.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11092625

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11092625