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Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years.
Bar-Haim, Erez; Eliakim-Raz, Noa; Stemmer, Amos; Cohen, Hila; Elia, Uri; Ness, Asaf; Awwad, Muhammad; Ghantous, Nassem; Moskovits, Neta; Rotem, Shahar; Stemmer, Salomon M.
  • Bar-Haim E; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 7410001, Israel.
  • Eliakim-Raz N; Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva 4941492, Israel.
  • Stemmer A; Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tikva 4941492, Israel.
  • Cohen H; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Elia U; Department of Oncology, Sheba Medical Center, Tel Hashomer, Ramat Gan 5224213, Israel.
  • Ness A; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 7410001, Israel.
  • Awwad M; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 7410001, Israel.
  • Ghantous N; Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva 4941492, Israel.
  • Moskovits N; Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva 4941492, Israel.
  • Rotem S; Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva 4941492, Israel.
  • Stemmer SM; Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
J Clin Med ; 11(9)2022 May 08.
Article in English | MEDLINE | ID: covidwho-1847362
ABSTRACT
Both humoral and cellular anamnestic responses are significant for protective immunity against SARS-CoV-2. In the current study, the responses in elderly people before and after a fourth vaccine dose of BNT162b2 were compared to those of individuals immunized with three vaccine doses. Although a boost effect was observed, the high response following the third administration questions the necessity of an early fourth boost.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11092649

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11092649