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New-onset acute ischemic stroke following COVID-19: A case-control study.
Khorvash, Fariborz; Najafi, Mohammad Amin; Kheradmand, Mohsen; Saadatnia, Mohammad; Chegini, Rojin; Najafi, Farideh.
  • Khorvash F; Department of Neurology, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Najafi MA; Department of Neurology, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Kheradmand M; Department of Neurology, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Saadatnia M; Department of Neurology, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Chegini R; Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Najafi F; Department of Orthopedic, Rothman Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
J Res Med Sci ; 27: 31, 2022.
Article in English | MEDLINE | ID: covidwho-1847494
ABSTRACT

Background:

Neurological manifestations of coronavirus disease 2019 (COVID-19) have been highlighted. COVID-19 potentially increases the risk of thromboembolism. We aimed to compare patients with COVID-19 with and without new-onset acute ischemic stroke (AIS). Materials and

Methods:

In this single-center retrospective case-control study, demographics, clinical characteristics, laboratory findings, and clinical outcomes were compared between 51 patients with both COVID-19 and AIS (group A) and 160 patients with COVID-19 and without AIS (group B).

Results:

Patients in group A were significantly older, more likely to present with critical COVID-19 (P = 0.004), had higher rates of admission in the intensive care unit (P < 0.001), more duration of hospitalization (P < 0.001), and higher in-hospital mortality (P < 0.001). At the time of hospitalization, O2 saturation (P = 0.011), PH (P = 0.04), and HCO3 (P = 0.005) were lower in group A. White blood cell count (P = 0.002), neutrophil count (P < 0.001), neutrophil-lymphocyte ratio (P = 0.001), D-Dimer (P < 0.001), blood urea nitrogen (BUN) (P < 0.001), and BUN/Cr ratio (P < 0.001) were significantly higher in patients with AIS.

Conclusion:

Stroke in COVID-19 is multifactorial. In addition to conventional risk factors of ischemic stroke (age and cardiovascular risk factors), we found that patients with more severe COVID-19 are more prone to ischemic stroke. Furthermore, leukocyte count, neutrophil count, neutrophil-lymphocyte ratio, D-Dimer, BUN, and BUN/Cr ratio were higher in patients with AIS following COVID-19 infection.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: J Res Med Sci Year: 2022 Document Type: Article Affiliation country: Jrms.jrms_255_21

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: J Res Med Sci Year: 2022 Document Type: Article Affiliation country: Jrms.jrms_255_21