Dose-response relationship between risk factors and incidence of COVID-19 in 325 hospitalized patients: A multicenter retrospective cohort study.
World J Clin Cases
; 10(10): 3047-3059, 2022 Apr 06.
Article
in English
| MEDLINE | ID: covidwho-1847752
ABSTRACT
BACKGROUND:
The epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients have been widely reported, but the assessment of dose-response relationships and risk factors for mortality and severe cases and clinical outcomes remain unclear.AIM:
To determine the dose-response relationship between risk factors and incidence of COVID-19.METHODS:
In this retrospective, multicenter cohort study, we included patients with confirmed COVID-19 infection who had been discharged or had died by February 6, 2020. We used multivariable logistic regression and Cox proportional hazard models to determine the dose-response relationship between risk factors and incidence of COVID-19.RESULTS:
It clarified that increasing risk of in-hospital death were associated with older age (HR 1.04, 95%CI 1.01-1.09), higher lactate dehydrogenase [HR 1.04, 95% confidence interval (CI) 1.01-1.10], C-reactive protein (HR 1.10, 95%CI 1.01-1.23), and procalcitonin (natural log-transformed HR 1.88, 95%CI 1.22-2.88), and D-dimer greater than 1 µg/mL at admission (natural log transformed HR 1.63, 95%CI 1.03-2.58) by multivariable regression. D-dimer and procalcitonin were logarithmically correlated with COVID-19 mortality risk, while there was a linear dose-response correlation between age, lactate dehydrogenase, D-dimer and procalcitonin, independent of established risk factors.CONCLUSION:
Higher lactate dehydrogenase, D-dimer, and procalcitonin levels were independently associated with a dose-response increased risk of COVID-19 mortality.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Language:
English
Journal:
World J Clin Cases
Year:
2022
Document Type:
Article
Affiliation country:
Wjcc.v10.i10.3047
Similar
MEDLINE
...
LILACS
LIS