Potential intestinal infection and faecal-oral transmission of human coronaviruses.
Rev Med Virol
; 32(6): e2363, 2022 11.
Article
in English
| MEDLINE | ID: covidwho-1850235
ABSTRACT
Human coronaviruses (HCoVs) were first described in 1960s for patients experiencing common cold. Since then, increasing number of HCoVs have been discovered, including those causing severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the circulating coronavirus disease 2019 (COVID-19), which can cause fatal respiratory disease in humans on infection. HCoVs are believed to spread mainly through respiratory droplets and close contact. However, studies have shown that a large proportion of patients with HCoV infection develop gastrointestinal (GI) symptoms, and many patients with confirmed HCoV infection have shown detectable viral RNA in their faecal samples. Furthermore, multiple in vitro and in vivo animal studies have provided direct evidence of intestinal HCoV infection. These data highlight the nature of HCoV GI infection and its potential faecal-oral transmission. Here, we summarise the current findings on GI manifestations of HCoVs. We also discuss how HCoV GI infection might occur and the current evidence to establish the occurrence of faecal-oral transmission.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Common Cold
/
Severe acute respiratory syndrome-related coronavirus
/
Middle East Respiratory Syndrome Coronavirus
/
COVID-19
Limits:
Animals
/
Humans
Language:
English
Journal:
Rev Med Virol
Journal subject:
Virology
Year:
2022
Document Type:
Article
Affiliation country:
Rmv.2363
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