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Animal models for studying coronavirus infections and developing antiviral agents and vaccines.
Lin, Qisheng; Lu, Chunni; Hong, Yuqi; Li, Runfeng; Chen, Jinding; Chen, Weisan; Chen, Jianxin.
  • Lin Q; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
  • Lu C; Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria 3168, Australia.
  • Hong Y; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
  • Li R; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou Medical University, Guangzhou, Guangdong, 510120, China.
  • Chen J; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
  • Chen W; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia. Electronic address: weisan.chen@latrobe.edu.au.
  • Chen J; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: jxchen@scau.edu.cn.
Antiviral Res ; 203: 105345, 2022 07.
Article in English | MEDLINE | ID: covidwho-1850639
ABSTRACT
In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six million deaths worldwide and it is likely the biggest pandemic of this century faced by mankind. Although many studies on SARS-CoV-2 have been conducted, a detailed understanding of SARS-CoV-2 and COVID-19 is still lacking. Animal models are indispensable for studying its pathogenesis and developing vaccines and antivirals. In this review, we analyze animal models of coronavirus infections and explore their applications on antivirals and vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / Middle East Respiratory Syndrome Coronavirus / COVID-19 / COVID-19 Drug Treatment Topics: Vaccines Limits: Animals Language: English Journal: Antiviral Res Year: 2022 Document Type: Article Affiliation country: J.antiviral.2022.105345

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / Middle East Respiratory Syndrome Coronavirus / COVID-19 / COVID-19 Drug Treatment Topics: Vaccines Limits: Animals Language: English Journal: Antiviral Res Year: 2022 Document Type: Article Affiliation country: J.antiviral.2022.105345