Boosting extracellular vesicle secretion.
Biotechnol Adv
; 59: 107983, 2022 10.
Article
in English
| MEDLINE | ID: covidwho-1850715
ABSTRACT
In recent years, extracellular vesicles (EVs), specifically exosomes, have emerged as a promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID-19, as well as promoting tissue regeneration in various conditions, including cardiomyopathies and spinal cord injuries. Despite the great potential of EV-based therapies, poor yield and unscalable production of EVs remain big challenges to overcome to translate these types of treatment to clinical practices. Here, we review different strategies for enhancing EV yield by physical, biological or chemical means. Some of these novel approaches can lead to about 100-fold increase in EV production yield, thus bringing closer the clinical translation with regard to scalability and efficiency.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Exosomes
/
Extracellular Vesicles
/
COVID-19
/
Neoplasms
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Biotechnol Adv
Year:
2022
Document Type:
Article
Affiliation country:
J.biotechadv.2022.107983
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