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Boosting extracellular vesicle secretion.
Debbi, Lior; Guo, Shaowei; Safina, Dina; Levenberg, Shulamit.
  • Debbi L; Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
  • Guo S; The First Affiliated Hospital, Shantou University Medical College, Shantou, China.
  • Safina D; Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
  • Levenberg S; Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address: shulamit@bm.technion.ac.il.
Biotechnol Adv ; 59: 107983, 2022 10.
Article in English | MEDLINE | ID: covidwho-1850715
ABSTRACT
In recent years, extracellular vesicles (EVs), specifically exosomes, have emerged as a promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID-19, as well as promoting tissue regeneration in various conditions, including cardiomyopathies and spinal cord injuries. Despite the great potential of EV-based therapies, poor yield and unscalable production of EVs remain big challenges to overcome to translate these types of treatment to clinical practices. Here, we review different strategies for enhancing EV yield by physical, biological or chemical means. Some of these novel approaches can lead to about 100-fold increase in EV production yield, thus bringing closer the clinical translation with regard to scalability and efficiency.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Exosomes / Extracellular Vesicles / COVID-19 / Neoplasms Type of study: Prognostic study Limits: Humans Language: English Journal: Biotechnol Adv Year: 2022 Document Type: Article Affiliation country: J.biotechadv.2022.107983

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Exosomes / Extracellular Vesicles / COVID-19 / Neoplasms Type of study: Prognostic study Limits: Humans Language: English Journal: Biotechnol Adv Year: 2022 Document Type: Article Affiliation country: J.biotechadv.2022.107983