Your browser doesn't support javascript.
Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents.
Han, Jinhe; Lee, Myoung Kyu; Jang, Yejin; Cho, Won-Jea; Kim, Meeheyin.
  • Han J; College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.
  • Lee MK; Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea.
  • Jang Y; Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea.
  • Cho WJ; College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address: wjcho@jnu.ac.kr.
  • Kim M; Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea; Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea. Electronic address: mkim@krict.re.kr.
Drug Discov Today ; 27(7): 1895-1912, 2022 07.
Article in English | MEDLINE | ID: covidwho-1850938
ABSTRACT
Cyclophilin A (CypA) is linked to diverse human diseases including viral infections. With the worldwide emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2), drug repurposing has been highlighted as a strategy with the potential to speed up antiviral development. Because CypA acts as a proviral component in hepatitis C virus, coronavirus and HIV, its inhibitors have been suggested as potential treatments for these infections. Here, we review the structure of cyclosporin A and sanglifehrin A analogs as well as synthetic micromolecules inhibiting CypA; and we discuss their broad-spectrum antiviral efficacy in the context of the virus lifecycle.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Drug Discov Today Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Drug Discov Today Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article