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COVID-19 vaccine booster dose needed to achieve Omicron-specific neutralisation in nursing home residents.
Canaday, David H; Oyebanji, Oladayo A; White, Elizabeth; Keresztesy, Debbie; Payne, Michael; Wilk, Dennis; Carias, Lenore; Aung, Htin; St Denis, Kerri; Sheehan, Maegan L; Berry, Sarah D; Cameron, Cheryl M; Cameron, Mark J; Wilson, Brigid M; Balazs, Alejandro B; King, Christopher L; Gravenstein, Stefan.
  • Canaday DH; Case Western Reserve University School of Medicine, Cleveland, OH; Geriatric Research, Education and Clinical Center, Cleveland VA. Electronic address: dxc44@case.edu.
  • Oyebanji OA; Case Western Reserve University School of Medicine, Cleveland, OH.
  • White E; Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI.
  • Keresztesy D; Case Western Reserve University School of Medicine, Cleveland, OH.
  • Payne M; Case Western Reserve University School of Medicine, Cleveland, OH.
  • Wilk D; Case Western Reserve University School of Medicine, Cleveland, OH.
  • Carias L; Case Western Reserve University School of Medicine, Cleveland, OH.
  • Aung H; Case Western Reserve University School of Medicine, Cleveland, OH.
  • St Denis K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA.
  • Sheehan ML; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA.
  • Berry SD; Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA.
  • Cameron CM; Case Western Reserve University School of Medicine, Cleveland, OH.
  • Cameron MJ; Case Western Reserve University School of Medicine, Cleveland, OH.
  • Wilson BM; Geriatric Research, Education and Clinical Center, Cleveland VA.
  • Balazs AB; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA.
  • King CL; Case Western Reserve University School of Medicine, Cleveland, OH.
  • Gravenstein S; Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI; Center on Innovation in Long-Term Services and Supports, Providence Veterans Administration Medical Center, Providence, RI; Division of Geriatrics and Palliative Medicine, Alpert Medical Sc
EBioMedicine ; 80: 104066, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1850958
ABSTRACT

BACKGROUND:

Nursing home (NH) residents have borne a disproportionate share of SARS-CoV-2 morbidity and mortality. Vaccines have limited hospitalisation and death from earlier variants in this vulnerable population. With the rise of Omicron and future variants, it is vital to sustain and broaden vaccine-induced protection. We examined the effect of boosting with BNT162b2 mRNA vaccine on humoral immunity and Omicron-specific neutralising activity among NH residents and healthcare workers (HCWs).

METHODS:

We longitudinally enrolled 85 NH residents (median age 77) and 48 HCWs (median age 51), and sampled them after the initial vaccination series; and just before and 2 weeks after booster vaccination. Anti-spike, anti-receptor binding domain (RBD) and neutralisation titres to the original Wuhan strain and neutralisation to the Omicron strain were obtained.

FINDINGS:

Booster vaccination significantly increased vaccine-specific anti-spike, anti-RBD, and neutralisation levels above the pre-booster levels in NH residents and HCWs, both in those with and without prior SARS-CoV-2 infection. Omicron-specific neutralisation activity was low after the initial 2 dose series with only 28% of NH residents' and 28% HCWs' titres above the assay's lower limit of detection. Omicron neutralising activity following the booster lifted 86% of NH residents and 93% of HCWs to the detectable range.

INTERPRETATION:

With boosting, the vast majority of HCWs and NH residents developed detectable Omicron-specific neutralising activity. These data provide immunologic evidence that strongly supports booster vaccination to broaden neutralising activity and counter waning immunity in the hope it will better protect this vulnerable, high-risk population against the Omicron variant.

FUNDING:

NIH AI129709-03S1, U01 CA260539-01, CDC 200-2016-91773, and VA BX005507-01.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Aged / Humans / Middle aged Language: English Journal: EBioMedicine Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Aged / Humans / Middle aged Language: English Journal: EBioMedicine Year: 2022 Document Type: Article