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Pearson's patterns correlational of clinical risks at admissions with hospitalization outcomes during initial COVID-19 outbreak.
Li, Jingwen; Long, Xi; Zhang, Qing; Fang, Xi; Luo, Huiling; Fang, Fang; Lv, Xuefei; Zhang, Dandan; Sun, Yu; Li, Na; Hu, Shaoping; Li, Jinghong; Xiong, Nian; Lin, Zhicheng.
  • Li J; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Long X; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Zhang Q; Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Fang X; Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Luo H; Department of Anesthesiology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Fang F; Department of Radiology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Lv X; Department of Radiology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Zhang D; Department of Radiology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Sun Y; Department of Radiology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Li N; Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Hu S; Department of Radiology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Li J; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Xiong N; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Lin Z; Wuhan Red Cross Hospital, Wuhan, Hubei, China.
iScience ; 25(6): 104415, 2022 Jun 17.
Article in English | MEDLINE | ID: covidwho-1851360
ABSTRACT
COVID-19 outbreaks have crushed our healthcare systems, which requires clinical guidance for the healthcare following the outbreaks. We conducted retrospective cohort studies with Pearson's pattern-based analysis of clinical parameters of 248 hospitalized patients with COVID-19. We found that dysregulated neutrophil densities were correlated with hospitalization duration before death (p = 0.000066, r = -0.45 for % neutrophil; p = 0.0001, r = -0.47 for neutrophil count). As such, high neutrophil densities were associated with mortality (p = 4.23 × 10-31 for % neutrophil; p = 4.14 × 10-27 for neutrophil count). These findings were further illustrated by a representative "second week crash" pattern and validated by an independent cohort (p = 5.98 × 10-11 for % neutrophil; p = 1.65 × 10-7 for neutrophil count). By contrast, low aspartate aminotransferase (AST) or lactate dehydrogenase (LDH) levels were correlated with quick recovery (p ≤ 0.00005). Collectively, these correlational at-admission findings may provide healthcare guidance for patients with COVID-19 in the absence of targeted therapy.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: IScience Year: 2022 Document Type: Article Affiliation country: J.isci.2022.104415

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: IScience Year: 2022 Document Type: Article Affiliation country: J.isci.2022.104415