Applications of Brain Organoids for Infectious Diseases.
J Mol Biol
; 434(3): 167243, 2022 02 15.
Article
in English
| MEDLINE | ID: covidwho-1851574
ABSTRACT
Brain organoids are self-organized three-dimensional aggregates generated from pluripotent stem cells. They exhibit complex cell diversities and organized architectures that resemble human brain development ranging from neural tube formation, neuroepithelium differentiation, neurogenesis and gliogenesis, to neural circuit formation. Rapid advancements in brain organoid culture technologies have allowed researchers to generate more accurate models of human brain development and neurological diseases. These models also allow for direct investigation of pathological processes associated with infectious diseases affecting the nervous system. In this review, we first briefly summarize recent advancements in brain organoid methodologies and neurodevelopmental processes that can be effectively modeled by brain organoids. We then focus on applications of brain organoids to investigate the pathogenesis of neurotropic viral infection. Finally, we discuss limitations of the current brain organoid methodologies as well as applications of other organ specific organoids in the infectious disease research.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Brain
/
Organoids
/
Central Nervous System Viral Diseases
Limits:
Humans
Language:
English
Journal:
J Mol Biol
Year:
2022
Document Type:
Article
Affiliation country:
J.jmb.2021.167243
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