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The impact of COVID-19 on people with multiple sclerosis: A comparison of Italian and United States cohorts.
Schwartz, Carolyn E; Rapkin, Bruce D; Bonavita, Simona; Bossa, Michela; Buscarinu, Maria Chiara; Grasso, Maria Grazia; Luca, Maria; Nozzolillo, Agostino; Nocentini, Ugo.
  • Schwartz CE; DeltaQuest Foundation, Inc., Concord, MA, USA; Departments of Medicine and Orthopaedic Surgery, Tufts University Medical School, Boston, MA, USA. Electronic address: carolyn.schwartz@deltaquest.org.
  • Rapkin BD; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Bonavita S; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Bossa M; Behavioral Neuropsychology Laboratory, IRCCS S. Lucia Foundation, Rome, Italy.
  • Buscarinu MC; Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy; Neuroimmunology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy.
  • Grasso MG; Multiple Sclerosis Unit, IRCCS S. Lucia Foundation, Rome, Italy.
  • Luca M; Department "GF Ingrassia", Section of Neurosciences, University of Catania, Catania, Italy; Centre for addiction, Via Pò 2, 95031, Adrano, Italy.
  • Nozzolillo A; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Nocentini U; Behavioral Neuropsychology Laboratory, IRCCS S. Lucia Foundation, Rome, Italy; Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
Mult Scler Relat Disord ; 63: 103888, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1851848
ABSTRACT
BACKGROUND/

OBJECTIVES:

The present cross-national study addressed the relationship among three pandemic-related variables and multiple sclerosis (MS) disability outcomes among people with MS in Italy and the United States (US).

METHODS:

This cross-sectional web-based study was administered to 708 patients with MS from the US and Italy in late Spring through mid-Summer of 2020. Pandemic-related variables assessed worry, self-protection, and post-traumatic growth. The Performance Scales© assessed MS disability. Multivariate multiple regression models addressed, separately by country, the relationship among worry, protection, and post-traumatic growth with MS disability, after covariate adjustment.

RESULTS:

The Italian sample (n = 292) was younger and less disabled than the US group (n = 416). After covariate adjustment, all three pandemic-related variables were associated with MS disability outcomes in the US sample, but only worry and post-traumatic growth were associated in the Italian sample. Worse cognitive and depression symptoms were associated with worry, and lesser mobility disability was associated with endorsed growth in both countries. More disability variables were associated with worry and growth in the Italian sample.

CONCLUSIONS:

The pandemic's negative aspects were associated with worse disability in both countries, and reported post-traumatic growth was associated with lesser disability. These findings may suggest directions for clinical intervention.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Multiple Sclerosis Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Topics: Long Covid Limits: Humans Country/Region as subject: North America Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Multiple Sclerosis Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Topics: Long Covid Limits: Humans Country/Region as subject: North America Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article