COVID-19 & differential effects in twins: Insights from Placenta Pathology.
Placenta
; 124: 62-66, 2022 06 24.
Article
in English
| MEDLINE | ID: covidwho-1914906
ABSTRACT
INTRODUCTION:
COVID-19 has been associated with several adverse pregnancy outcomes, including perinatal loss. Differential effects of COVID-19 in a twin pregnancy may provide unique insights into virus-placental interactions. We present a case of perinatal loss of a female fetus with survival of the male co-twin in a pregnancy complicated by COVID-19 and premature delivery.METHODS:
Viral detection methods recommended by the NICHD task force were used to identify SARS-CoV-2 and its viral receptors in the placentas and fetal tissue (Antoun et al., 2020) [1]RESULTS:
Compared with the surviving twin, we found a more severe intervillous necrosis and a relatively low detection of ACE2 membranous expression in the syncytiotrophoblasts of the female twin that succumbed.DISCUSSION:
The interactions of SARS-CoV-2 and ACE2 at the maternal fetal interface within the placenta may play a significant role in perinatal loss, and the effects of fetal sex and gestational age at time of infection need to be explored further.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
COVID-19
Type of study:
Case report
/
Experimental Studies
/
Prognostic study
Limits:
Female
/
Humans
/
Male
/
Pregnancy
Language:
English
Journal:
Placenta
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS