Glycosylation as a key parameter in the design of nucleic acid vaccines.
Curr Opin Struct Biol
; 73: 102348, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1852025
ABSTRACT
Vaccine-induced immunity is expected to target the native antigens expressed by the pathogens. Therefore, it is highly important to generate vaccine antigens that are immunologically indistinguishable from the native antigens. Nucleic acid vaccines, comprised of DNA, mRNA, or recombinant viral vector vaccines, introduce the genetic material encoding the antigenic protein for the host to express. Because these proteins will undergo host posttranslational modifications, host glycosylation can potentially alter the structure and immunological efficacy of the antigen. In this review, we discuss the potential impact of host protein glycosylation on the immune responses generated by nucleic acid vaccines against bacterial and viral pathogens.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viral Vaccines
/
Nucleic Acid-Based Vaccines
Topics:
Vaccines
Language:
English
Journal:
Curr Opin Struct Biol
Journal subject:
Molecular Biology
Year:
2022
Document Type:
Article
Affiliation country:
J.sbi.2022.102348
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