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Effects of statins on the risks of ischemic stroke and heart disease in human immunodeficiency virus infection, influenza and severe acute respiratory syndrome-associated coronavirus: respiratory virus infection with steroid use.
Yeh, Jun-Jun; Lai, Meichu; Lin, Cheng-Li; Lu, Kuan-Hua; Kao, Chia-Hung.
  • Yeh JJ; Department of Family Medicine, Geriatric Medicine, and Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.
  • Lai M; College of Medicine, China Medical University, Taichung, Taiwan.
  • Lin CL; Department of Laboratory Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.
  • Lu KH; College of Medicine, China Medical University, Taichung, Taiwan.
  • Kao CH; Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
Postgrad Med ; 134(6): 589-597, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1852656
ABSTRACT

OBJECTIVES:

We sought to fill the research gap on the effects of statins on the risks of ischemic stroke and heart disease among individuals with human immunodeficiency virus infection, influenza, and severe acute respiratory syndrome associated-coronavirus (HIS) disorders.

METHODS:

We enrolled a HIS cohort treated with statins (n = 4921) and a HIS cohort not treated with statins (n = 4921). The cumulative incidence of ischemic stroke and heart disease was analyzed using a time-dependent Cox proportional regression analysis. We analyzed the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of ischemic stroke and heart disease for statins users relative to nonusers based on sex, age, comorbidities and medications.

RESULTS:

The aHR (95% CI) was 0.38 (0.22-0.65) for ischemic stroke. The aHR (95% CI) of heart disease was 0.50 (0.46-0.55). The aHRs (95% CI) of statin users with low, medium, and high adherence (statin use covering <33%, 33%-66%, and >66%, respectively, of the study period) for the risks of ischemic stroke were 0.50 (0.27-0.92), 0.31 (0.10-1.01), and 0.16 (0.04-0.68) and for heart disease were 0.56 (0.51-0.61), 0.40 (0.33-0.48), and 0.44 (0.38-0.51), respectively, compared with statin nonusers.

CONCLUSION:

Statin use was associated with lower aHRs for ischemic stroke and heart disease in those with HIS disorders with comorbidities.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Coronavirus / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Stroke / Influenza, Human / Ischemic Stroke / Heart Diseases Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Postgrad Med Year: 2022 Document Type: Article Affiliation country: 00325481.2022.2080359

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Coronavirus / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Stroke / Influenza, Human / Ischemic Stroke / Heart Diseases Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Postgrad Med Year: 2022 Document Type: Article Affiliation country: 00325481.2022.2080359