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Kikuchi-Fujimoto disease can present as delayed lymphadenopathy after COVID-19 vaccination.
Kashiwada, Takeru; Saito, Yoshinobu; Terasaki, Yasuhiro; Shirakura, Yukari; Shinbu, Kaoruko; Tanaka, Toru; Tanaka, Yosuke; Seike, Masahiro; Gemma, Akihiko.
  • Kashiwada T; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Saito Y; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Terasaki Y; Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Shirakura Y; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Shinbu K; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Tanaka T; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Tanaka Y; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Seike M; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Gemma A; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Hum Vaccin Immunother ; 18(5): 2071080, 2022 11 30.
Article in English | MEDLINE | ID: covidwho-1852828
ABSTRACT
Following COVID-19 vaccination, ipsilateral axillary and cervical lymphadenopathy may occur, called vaccine-related hypermetabolic lymphadenopathy, which is considered reactive lymphadenopathy. We report here a case of Kikuchi-Fujimoto disease, which occurred three months after vaccination with COVID-19 vaccine. The patient had cervical and axillary lymph node enlargement and a short-term fever that resolved spontaneously after the first and second vaccines. On the 90th day after the first vaccination, the patient developed a high fever and pathologically diagnosed necrotizing lymphadenitis in the axilla, which was diagnosed as Kikuchi-Fujimoto disease. Gallium scintigraphy showed localized swelling and strong uptake in the ipsilateral axilla. It implies the possibility of Kikuchi-Fujimoto Disease in axillary drainage lymph nodes in association with COVID-19 vaccine. Although only a few cases have been reported so far, this case is novel because of its later onset and diagnosis based on pathological and gallium scintigraphy imaging findings.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Histiocytic Necrotizing Lymphadenitis / Lymphadenopathy / Gallium / COVID-19 Vaccines / COVID-19 Type of study: Case report / Diagnostic study / Observational study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Hum Vaccin Immunother Year: 2022 Document Type: Article Affiliation country: 21645515.2022.2071080

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Histiocytic Necrotizing Lymphadenitis / Lymphadenopathy / Gallium / COVID-19 Vaccines / COVID-19 Type of study: Case report / Diagnostic study / Observational study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Hum Vaccin Immunother Year: 2022 Document Type: Article Affiliation country: 21645515.2022.2071080