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ENGINEERED SCAFFOLDS FOR THE DELIVERY OF GENE THERAPEUTICS FOR ENHANCED TISSUE REPAIR
Tissue Engineering - Part A ; 28(SUPPL 1):S649, 2022.
Article in English | EMBASE | ID: covidwho-1852886
ABSTRACT
The COVID-19 pandemic has shown how revolutionary treatments based on gene therapeutics has helped overcome a once-in-acentury pandemic and has given new momentum to gene therapy research for a myriad of applications. The field of regenerative medicine is well placed to be a beneficiary whereby, for example, gene therapy might be a valuable tool to avoid the limitations of local delivery of growth factors. While non-viral vectors are typically inefficient at transfecting cells, our group have had significant success in this area using a scaffold-mediated gene therapy approach for regenerative applications[1, 2]. These gene activated scaffold platforms not only act as a template for cell infiltration and tissue formation, but also can be engineered to direct autologous host cells to take up specific genes and then produce therapeutic proteins in a sustained but eventually transient fashion. Similarly, we have demonstrated how scaffold-mediated delivery of siRNAs[3] and miRNA[4, 5] can be used to silence specific genes associated with reduced repair or pathological states. This presentation will provide an overview of ongoing research in our lab in this area with a particular focus on gene-activated biomaterials for promoting bone, cartilage, nerve and wound repair. Focus will also be placed on advances we are making in using 3D printing of gene activated bioinks to produce next generation medical devices for tissue repair.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Tissue Engineering - Part A Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Tissue Engineering - Part A Year: 2022 Document Type: Article