Amyloid-beta-related angiitis: a treatable rapidly progressive dementia.

Nasir, Memoona; Nortey, Donald; Malek, Naveed; Valerio, Fernanda; Chaudhuri, Abhijit

Nasir, Memoona; Nortey, Donald; Malek, Naveed; Valerio, Fernanda; Chaudhuri, Abhijit.

Nasir M; Department of Neurology, Queen's Hospital, Romford, UK memoona.nasir@nhs.net.
Nortey D; Department of Neurology, Queen's Hospital, Romford, UK.
Malek N; Department of Neurology, Queen's Hospital, Romford, UK.
Valerio F; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK.
Chaudhuri A; Department of Neurology, Queen's Hospital, Romford, UK.

Pract Neurol ; 22(3): 228-230, 2022 Jun.

Article in English | MEDLINE | ID: covidwho-1854394

ABSTRACT

ABSTRACT

A 73-year-old woman developed cognitive decline over 1 year. MR scan of the brain showed a focal asymmetrical leukoencephalopathy involving the right frontal, temporal, parietal and occipital lobes. Extensive laboratory investigations found no cause but brain biopsy identified amyloid-beta-related angiitis (ABRA), a potentially treatable cause of rapid-onset dementia. We gave intravenous methylprednisolone and then two courses of intravenous cyclophosphamide, after which her cognitive skills gradually but significantly improved over several months.

Subject(s)

Dementia; Vasculitis; Aged; Amyloid beta-Peptides/metabolism; Biopsy; Brain/pathology; Dementia/complications; Dementia/diagnostic imaging; Dementia/drug therapy; Female; Humans; Vasculitis/pathology

Keywords

dementia

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vasculitis / Dementia Type of study: Case report Topics: Long Covid Limits: Aged / Female / Humans Language: English Journal: Pract Neurol Year: 2022 Document Type: Article Affiliation country: Practneurol-2021-003263

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