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Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection.
McGary, Lisa H F; Vardhana, Santosha A.
  • McGary LHF; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, New York.
  • Vardhana SA; Tri-Institutional MD-PhD Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Cancer Discov ; 12(4): 892-894, 2022 04 01.
Article in English | MEDLINE | ID: covidwho-1854525
ABSTRACT

SUMMARY:

Fahrner and colleagues investigated the immune response of patients with cancer and cancer-free individuals to SARS-CoV-2 and found that a propensity toward an IL5-predominant Th2/Tc2 response was predictive of susceptibility to infection. The results of this study also suggest that a cellular response against the Spike 1 protein receptor binding domain (S1-RBD) region of the SARS-CoV-2 proteome contributes to protection and that mutations in this region may drive viral evolution and immune escape. See related article by Fahrner et al., p. 958 (8).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Cancer Discov Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Cancer Discov Year: 2022 Document Type: Article