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Patients with CLL have a lower risk of death from COVID-19 in the Omicron era.
Niemann, Carsten U; da Cunha-Bang, Caspar; Helleberg, Marie; Ostrowski, Sisse R; Brieghel, Christian.
  • Niemann CU; Department of Hematology, Rigshospitalet, Copenhagen, Denmark.
  • da Cunha-Bang C; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Helleberg M; Department of Hematology, Rigshospitalet, Copenhagen, Denmark.
  • Ostrowski SR; Department of Infectious Diseases.
  • Brieghel C; Center of Excellence for Health, Immunity and Infections, and.
Blood ; 140(5): 445-450, 2022 08 04.
Article in English | MEDLINE | ID: covidwho-1854761
ABSTRACT
Previous studies have shown that patients with chronic lymphocytic leukemia (CLL) and coronavirus disease 2019 (COVID-19) have high mortality rates. Infection with the Omicron variant has been described as a milder disease course in the general population. However, the outcome for immunocompromised patients has not previously been reported. In a cohort of patients with CLL tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at hospital test sites in the time periods before and after dominance of the Omicron variant, rates of hospitalizations and intensive care unit admissions declined significantly, whereas 30-day mortality remained as high as 23% in the period with dominance of the Omicron sublineage BA.2 variant. However, for a larger population-based cohort of patients with CLL (including the hospital cohort), 30-day mortality was 2%. Thus, patients with CLL with close hospital contacts and, in particular, those >70 years of age with 1 or more comorbidities should be considered for closer monitoring and preemptive antiviral therapy upon a positive SARS-CoV-2 test.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukemia, Lymphocytic, Chronic, B-Cell / COVID-19 Type of study: Etiology study / Risk factors Topics: Variants Limits: Humans Language: English Journal: Blood Year: 2022 Document Type: Article Affiliation country: Blood.2022016147

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukemia, Lymphocytic, Chronic, B-Cell / COVID-19 Type of study: Etiology study / Risk factors Topics: Variants Limits: Humans Language: English Journal: Blood Year: 2022 Document Type: Article Affiliation country: Blood.2022016147