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Infectious disease-associated encephalopathies.
Barbosa-Silva, Maria C; Lima, Maiara N; Battaglini, Denise; Robba, Chiara; Pelosi, Paolo; Rocco, Patricia R M; Maron-Gutierrez, Tatiana.
  • Barbosa-Silva MC; Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Av. Brasil, 4365, Pavilhão 108, sala 45, Manguinhos, Rio de Janeiro, RJ, 21040-360, Brazil.
  • Lima MN; Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Av. Brasil, 4365, Pavilhão 108, sala 45, Manguinhos, Rio de Janeiro, RJ, 21040-360, Brazil.
  • Battaglini D; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy.
  • Robba C; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy.
  • Pelosi P; Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
  • Rocco PRM; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy.
  • Maron-Gutierrez T; Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Crit Care ; 25(1): 236, 2021 07 06.
Article in English | MEDLINE | ID: covidwho-1854835
ABSTRACT
Infectious diseases may affect brain function and cause encephalopathy even when the pathogen does not directly infect the central nervous system, known as infectious disease-associated encephalopathy. The systemic inflammatory process may result in neuroinflammation, with glial cell activation and increased levels of cytokines, reduced neurotrophic factors, blood-brain barrier dysfunction, neurotransmitter metabolism imbalances, and neurotoxicity, and behavioral and cognitive impairments often occur in the late course. Even though infectious disease-associated encephalopathies may cause devastating neurologic and cognitive deficits, the concept of infectious disease-associated encephalopathies is still under-investigated; knowledge of the underlying mechanisms, which may be distinct from those of encephalopathies of non-infectious cause, is still limited. In this review, we focus on the pathophysiology of encephalopathies associated with peripheral (sepsis, malaria, influenza, and COVID-19), emerging therapeutic strategies, and the role of neuroinflammation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Diseases / Cytokines / Sepsis / Influenza, Human / COVID-19 / Malaria Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Crit Care Year: 2021 Document Type: Article Affiliation country: S13054-021-03659-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Diseases / Cytokines / Sepsis / Influenza, Human / COVID-19 / Malaria Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Crit Care Year: 2021 Document Type: Article Affiliation country: S13054-021-03659-6