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Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients.
Surme, Serkan; Tuncer, Gulsah; Bayramlar, Osman F; Copur, Betul; Zerdali, Esra; Nakir, Inci Y; Yazla, Meltem; Buyukyazgan, Ahmet; Cinar, Ayse Rk; Kurekci, Yesim; Alkan, Mustafa; Ozdemir, Yusuf E; Sengoz, Gonul; Pehlivanoglu, Filiz.
  • Surme S; Department of Infectious Diseases & Clinical Microbiology, Haseki Training & Research Hospital, Istanbul, 34096, Turkey.
  • Tuncer G; Department of Medical Microbiology, Institute of Graduate Studies, Istanbul University-Cerrahpasa, Istanbul, 34098, Turkey.
  • Bayramlar OF; Department of Infectious Diseases & Clinical Microbiology, Haseki Training & Research Hospital, Istanbul, 34096, Turkey.
  • Copur B; Department of Public Health, Bakirkoy District Health Directorate, Istanbul, 34140, Turkey.
  • Zerdali E; Department of Infectious Diseases & Clinical Microbiology, Haseki Training & Research Hospital, Istanbul, 34096, Turkey.
  • Nakir IY; Department of Infectious Diseases & Clinical Microbiology, Haseki Training & Research Hospital, Istanbul, 34096, Turkey.
  • Yazla M; Department of Infectious Diseases & Clinical Microbiology, Haseki Training & Research Hospital, Istanbul, 34096, Turkey.
  • Buyukyazgan A; Department of Infectious Diseases & Clinical Microbiology, Haseki Training & Research Hospital, Istanbul, 34096, Turkey.
  • Cinar AR; Department of Infectious Diseases & Clinical Microbiology, Bahcelievler State Hospital, Istanbul, 34186, Turkey.
  • Kurekci Y; Department of Infectious Diseases & Clinical Microbiology, Bayrampasa State Hospital, Istanbul, 34040, Turkey.
  • Alkan M; Department of Infectious Diseases & Clinical Microbiology, Arnavutkoy State Hospital, Istanbul, 34275, Turkey.
  • Ozdemir YE; Department of Infectious Diseases & Clinical Microbiology, Gaziosmanpasa Training & Research Hospital, Istanbul, 34255, Turkey.
  • Sengoz G; Department of Infectious Diseases & Clinical Microbiology, Bakirkoy Sadi Konuk Training & Research Hospital, Istanbul, 34147, Turkey.
  • Pehlivanoglu F; Department of Infectious Diseases & Clinical Microbiology, Haseki Training & Research Hospital, Istanbul, 34096, Turkey.
Biomark Med ; 16(8): 577-588, 2022 06.
Article in English | MEDLINE | ID: covidwho-1855267
ABSTRACT

Background:

The aim was to explore a novel risk score to predict mortality in hospitalized patients with COVID-19 pneumonia.

Methods:

This was a retrospective, multicenter study.

Results:

A total of 1013 patients with COVID-19 were included. The mean age was 60.5 ± 14.4 years, and 581 (57.4%) patients were male. In-hospital death occurred in 124 (12.2%) patients. Multivariate analysis revealed peripheral capillary oxygen saturation (SpO2), albumin, D-dimer and age as independent predictors. The mortality score model was given the acronym SAD-60, representing SpO2, Albumin, D-dimer, age ≥60 years. The SAD-60 score (0.776) had the highest area under the curve compared with CURB-65 (0.753), NEWS2 (0.686) and qSOFA (0.628) scores.

Conclusion:

The SAD-60 score has a promising predictive capacity for mortality in hospitalized patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Controlled clinical trial / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Biomark Med Journal subject: Biochemistry / Medicine Year: 2022 Document Type: Article Affiliation country: Bmm-2021-1085

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Controlled clinical trial / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Biomark Med Journal subject: Biochemistry / Medicine Year: 2022 Document Type: Article Affiliation country: Bmm-2021-1085