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Copeptin: a neuroendocrine biomarker of COVID-19 severity.
Hammad, Reham; Elshafei, Ahmed; Khidr, Emad Gamil; El-Husseiny, Ahmed A; Gomaa, Maher H; Kotb, Hend G; Eltrawy, Heba H; Farhoud, Hesham.
  • Hammad R; Department of Clinical Pathology, Faculty of Medicine (Girls), Al-Azhar University, Cairo, 11884, Egypt.
  • Elshafei A; Biochemistry & Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
  • Khidr EG; Biochemistry & Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
  • El-Husseiny AA; Biochemistry & Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
  • Gomaa MH; Biochemistry & Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
  • Kotb HG; Internal Medicine Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, 11884, Egypt.
  • Eltrawy HH; Chest Diseases Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, 11884, Egypt.
  • Farhoud H; Orthopedic Surgery Department, Dean of Faculty of Medicine (Girls), Al-Azhar University, Cairo, 11884, Egypt.
Biomark Med ; 16(8): 589-597, 2022 06.
Article in English | MEDLINE | ID: covidwho-1855268
ABSTRACT

Aim:

To investigate the change in a serum level of copeptin, a neuroendocrine biomarker, in differentiating grades of COVID-19 severity on admission time and to find its diagnostic potential. Materials &

Methods:

160 COVID-19 patients were classified according to disease severity into 80 mild to moderate and 80 severe patients. Serum copeptin level was assessed by ELISA on their admission time. Besides, serum CRP, ferritin and D-dimer were estimated.

Results:

Severe COVID-19 patients showed higher serum copeptin level in comparison to mild to moderate cases, with diagnostic potential to distinguish disease severity with 93.33% sensitivity and 100% specificity at cutoff value >18.5 Pmol/l.

Conclusion:

Serum copeptin was remarkably increased with COVID-19 severity with reasonable differentiation potential for recently admitted patients.
We conducted a biochemical study on the role of copeptin ­ a biomarker of acute stress due to COVID-19 infection ­ in classification of COVID-19 severity on admission over 160 adult patients. Copeptin was highly elevated in severe cases more than the mild to moderate ones. So, it may be an early marker in admission departments to ease early clinical decisions and medical intervention.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Biomark Med Journal subject: Biochemistry / Medicine Year: 2022 Document Type: Article Affiliation country: Bmm-2021-1100

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Biomark Med Journal subject: Biochemistry / Medicine Year: 2022 Document Type: Article Affiliation country: Bmm-2021-1100