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Evaluation of rapid antigen detection kits for detection of SARS-CoV-2 B.1.617.2 virus.
Mak, Gannon Ck; Lau, Stephen Sy; Wong, Kitty Ky; Chow, Nancy Ls; Lau, Chi-Shan; Lam, Edman Tk; Ng, Ken Hl; Chan, Rickjason Cw.
  • Mak GC; Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
  • Lau SS; Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
  • Wong KK; Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
  • Chow NL; Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
  • Lau CS; Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
  • Lam ET; Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
  • Ng KH; Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
  • Chan RC; Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
Future Virol ; 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1855272
ABSTRACT

Aim:

Currently, there is lack of data regarding rapid antigen detection (RAD) kits to detect SARS-CoV-2 B.1.617.2 virus.

Objective:

The purpose of this evaluation is to assess analytical sensitivity of 12 RAD kits against SARS-CoV-2 B.1.617.2. Study

design:

Analytical sensitivity was determined by limit of detection (LOD). A serial tenfold dilution set from a respiratory specimen collected from a COVID-19 patient infected by SARS-CoV-2 B.1.617.2 was used. RT-PCR was used as a reference method.

Results:

The LOD results showed that 11 and one RAD kits were 100- and 1000-fold less sensitive than RT-PCR respectively.

Conclusion:

The results showed that the RAD kits evaluated in this study may be used for first-line screening of the SARS-CoV-2 B.1.617.2 variant.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies Topics: Variants Language: English Year: 2022 Document Type: Article Affiliation country: Fvl-2021-0229

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies Topics: Variants Language: English Year: 2022 Document Type: Article Affiliation country: Fvl-2021-0229