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Role of Neutrophils on the Ocular Surface.
Mun, Yongseok; Hwang, Jin Sun; Shin, Young Joo.
  • Mun Y; Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07442, Korea.
  • Hwang JS; Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul 07442, Korea.
  • Shin YJ; Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07442, Korea.
Int J Mol Sci ; 22(19)2021 Sep 27.
Article in English | MEDLINE | ID: covidwho-1855649
ABSTRACT
The ocular surface is a gateway that contacts the outside and receives stimulation from the outside. The corneal innate immune system is composed of many types of cells, including epithelial cells, fibroblasts, natural killer cells, macrophages, neutrophils, dendritic cells, mast cells, basophils, eosinophils, mucin, and lysozyme. Neutrophil infiltration and degranulation occur on the ocular surface. Degranulation, neutrophil extracellular traps formation, called NETosis, and autophagy in neutrophils are involved in the pathogenesis of ocular surface diseases. It is necessary to understand the role of neutrophils on the ocular surface. Furthermore, there is a need for research on therapeutic agents targeting neutrophils and neutrophil extracellular trap formation for ocular surface diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cell Degranulation / Cornea / Neutrophil Infiltration / Eye Diseases / Extracellular Traps / Neutrophils Type of study: Reviews Limits: Humans Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cell Degranulation / Cornea / Neutrophil Infiltration / Eye Diseases / Extracellular Traps / Neutrophils Type of study: Reviews Limits: Humans Language: English Year: 2021 Document Type: Article