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Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals: a retrospective observational study.
Ruiz-Comellas, Anna; Roura Poch, Pere; Sauch Valmaña, Glòria; Guadalupe-Fernández, Víctor; Mendioroz Peña, Jacobo; Miró Catalina, Queralt; Vidal-Alaball, Josep; Ramirez-Morros, Anna.
  • Ruiz-Comellas A; Centre d'Atenció Primària (CAP) Sant Joan de Vilatorrada. Gerència Territorial de la Catalunya Central, Institut Català de la Salut, Sant Fruitós de Bages, Spain.
  • Roura Poch P; Health Promotion in Rural Areas Research Group, Institut Català de la Salut, Sant Fruitós de Bages, Spain.
  • Sauch Valmaña G; Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, Spain.
  • Guadalupe-Fernández V; Faculty of Medicine, Universitat de Vic-Universitat Central de Catalunya, Vic, Spain.
  • Mendioroz Peña J; Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, Spain.
  • Miró Catalina Q; Faculty of Medicine, Universitat de Vic-Universitat Central de Catalunya, Vic, Spain.
  • Vidal-Alaball J; Consorci Sanitari de Vic, Hospital de Vic, Vic, Spain.
  • Ramirez-Morros A; Health Promotion in Rural Areas Research Group, Institut Català de la Salut, Sant Fruitós de Bages, Spain.
BJGP Open ; 6(2)2022 Jun.
Article in English | MEDLINE | ID: covidwho-1855866
ABSTRACT

BACKGROUND:

Among the manifestations of COVID-19 are taste and smell disorders (TSDs).

AIM:

To evaluate the sensitivity and specificity of TSDs and other associated symptoms to estimate predictive values for determining SARS-CoV-2 infection. DESIGN &

SETTING:

A retrospective observational study of healthcare professionals in Catalonia, Spain.

METHOD:

A study of the sensitivity and specificity of TSDs has been carried out using the polymerase chain reaction (PCR) test for the diagnosis of SARS-CoV-2 as the gold standard value. Logistic regressions adjusted for age and sex were performed to identify additional symptoms that might be associated with COVID-19.

RESULTS:

The results are based on 226 healthcare workers with clinical symptoms suggestive of COVID-19, 116 with positive PCR and 110 with negative PCR. TSDs had an odds ratio (OR) of 12.4 (95% confidence interval [CI] = 6.3 to 26.2), sensitivity 60.3% and specificity 89.1%. In the logistic regression model, the association of TSD, fever or low-grade fever, shivering, dyspnoea, arthralgia, and myalgia obtained an area under the curve (AUC) of 85.7% (95% CI = 80.7 % to 90.7 %), sensitivity 82.8 %, specificity 80.0%, and positive predictive values 81.4% and negative 81.5%.

CONCLUSION:

TSDs are a strong predictor of COVID-19. The association of TSD, fever, low-grade fever or shivering, dyspnoea, arthralgia, and myalgia correctly predicts 85.7% of the results of the COVID-19 test.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: BJGPO.2021.0141

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: BJGPO.2021.0141