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Understanding the diagnosis and management of multisystem inflammatory syndrome in adults (MIS-A) in the UK: results of a national Delphi process.
Hookham, Lauren; Fisher, Corinne; Manson, Jessica J; Morgan, Matt; O'Hara, Geraldine; Riley, Phil; Tattersall, Rachel S; Goodman, Anna L.
  • Hookham L; St George's University, London, UK lhookham@sgul.ac.uk.
  • Fisher C; University College Hospitals NHS Foundation Trust, London, UK.
  • Manson JJ; University College Hospitals NHS Foundation Trust, London, UK.
  • Morgan M; University Hospital of Wales, Cardiff, UK.
  • O'Hara G; Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Riley P; Manchester University NHS Foundation Trust, Manchester, UK.
  • Tattersall RS; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
  • Goodman AL; Guy's and St Thomas' NHS Foundation Trust, London, UK.
Clin Med (Lond) ; 22(3): 266-270, 2022 05.
Article in English | MEDLINE | ID: covidwho-1856279
ABSTRACT
Infection with SARS-CoV-2 may trigger a delayed hyper-inflammatory illness in children called paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS-TS). A similar syndrome is increasingly recognised in adults termed multisystem inflammatory syndrome in adults (MIS-A) and may present acutely to medical or surgical specialties with severe symptoms, such as acute abdominal pain or cardiogenic shock. No national guidelines exist in the UK for the management of MIS-A and there is limited evidence to guide treatment plans. We undertook a national Delphi process to elicit opinions from experts in hyperinflammation about the diagnosis and management of MIS-A with the dual aim of improving recognition and producing a management guideline. Colleagues in paediatrics successfully initiated a national consensus management document that facilitated regional multidisciplinary referral and follow-up pathways for children with PIMS-TS, and we propose a similar system be developed for adult patients across the UK. This would facilitate better recognition and treatment of MIS-A across the multiple specialties to which it may present as well as enable follow-up with specialty services post-discharge.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Prognostic study Topics: Long Covid Limits: Child / Humans Country/Region as subject: Europa Language: English Journal: Clin Med (Lond) Year: 2022 Document Type: Article Affiliation country: Clinmed.2021-0700

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Prognostic study Topics: Long Covid Limits: Child / Humans Country/Region as subject: Europa Language: English Journal: Clin Med (Lond) Year: 2022 Document Type: Article Affiliation country: Clinmed.2021-0700