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Neutrophil to Lymphocyte Ratio and the Severity of COVID-19 in Zagazig university hospitals
International Journal of Early Childhood Special Education ; 14(2):1288-1295, 2022.
Article in English | Web of Science | ID: covidwho-1856282
ABSTRACT

Background:

The elevated neutrophil to lymphocyte ratio (NLR) is significantly associated with the mortality and severity of patients with infectious diseases in general.Recent studies have suggested that NLR could be an effective predictor for the mortality of patients with COVID-19

Objective:

to assess NLR that can be used as prognostic marker in COVID-19 in order to help physicians to set up early treatment strategies.

Methods:

A cross-sectional study in isolation hospital of Zagazig University Hospitals after approval by institutional research board (IRB) conducted on 48 confirmed COVID-19 patients,we divided patients into two groups according to severity of symptoms into (mild and severe) Severe patients met at least one of the following conditions (1) Shortness of breath, RR >= 30 times/min, (2) Oxygen saturation (Resting state) <= 93%. All patients underwent a laboratory investigation with assessment of NLR.

Results:

There is statistically significant negative correlation between NLR and each of lymphocyte, platelet count, and serum albumin.Regarding respiratory rate and oxygen saturation, there is statistically significant positive correlation between NLR and respiratory rate, whereas negative correlation between NLR and oxygen saturation (r= 0.676, -0.632) respectively.NLR was found to be the strongest predictor 92.3%, accuracy 85.4% (p<0.001). So, according to our study NLR could discriminate COVID-19 severe patients from mild patients. The optimal cutoff of NLR in prediction of severe disease was >= 5.1464 in our study.

Conclusion:

Elevated NLR was an independent prognostic biomarker for COVID-19 patients. Therefore, the usable NLR are recommended as practical tools to assess prognosis and to evaluate the severity of clinical symptoms in COVID-19 patients.
Keywords

Full text: Available Collection: Databases of international organizations Database: Web of Science Type of study: Prognostic study Language: English Journal: International Journal of Early Childhood Special Education Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Web of Science Type of study: Prognostic study Language: English Journal: International Journal of Early Childhood Special Education Year: 2022 Document Type: Article