Morphological changes in leukocytes of acute SARS-CoV-2 infection patients, Amazon, Brazil
Medicina (Brazil)
; 55(1), 2022.
Article
in English
| EMBASE | ID: covidwho-1856329
ABSTRACT
Introduction:
The pandemic for the new coronavirus (SARS-CoV-2) brought many uncertainties about which laboratory parameters would be most suitable during the evolution of COVID 19.Objectives:
Correlate the results of the blood count (BC), the neutrophil/lymphocyte ratio (N/LR), the C-reactive protein (CRP) and morphological findings of individuals diagnosed with SARS-CoV-2 infection through Polymerase Chain Reaction in Real Time (RT-PCR) in a private laboratory in Belém, Pará, from March to September 2020. Materials andMethods:
Retrospective study with 30 individuals, of both sexes, any age and clinical complaint, of home or hospital origin who underwent BC, CRP and RT-PCR for COVID 19 until the 8th day of infection. Morphological changes were analyzed after selecting the slides for these patients.Results:
Sample composed of 15 men and 15 women, aged between 7 and 92 years. Of these 12/30 individuals were at home and 18/30 were hospitalized. The main complaints were fever, malaise, diarrhea and respiratory distress. The statistical study showed a direct dependency relationship between increases in N/LR, CRP and the need for hospitalization (p = 0.0005). Morphological analysis showed hyposegmented neutrophils with toxic granulations, vacuolated monocytes, and reactive lymphocytes with basophilic cytoplasm.Conclusion:
Our results associate intermediate and elevated levels of N/LR with increased CRP and disease severity, however, unrelated to the morphological findings in neutrophils, lymphocytes and monocytes that were common to all patients diagnosed up to the 8th day of infection.
adolescent; adult; aged; article; blood cell count; Brazil; child; clinical article; controlled study; coronavirus disease 2019; cytoplasm; diarrhea; female; fever; hospitalization; human; human cell; human tissue; leukocyte; lymphocyte; malaise; male; monocyte; neutrophil; neutrophil lymphocyte ratio; respiratory distress; retrospective study; severe acute respiratory syndrome
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Medicina (Brazil)
Year:
2022
Document Type:
Article
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