Effect of an Ayurvedic Intervention (Ayush-64) as a Stand-Alone Treatment in Mild to Moderate COVID-19: An Exploratory Prospective Single-Arm Clinical Trial
International Journal of Research in Pharmaceutical Sciences
; 13(1):68-72, 2022.
Article
in English
| EMBASE | ID: covidwho-1856628
ABSTRACT
An Ayurvedic polyherbal formulation (Ayush-64) was repurposed for use in mild to moderate COVID-19 cases based on the supportive evidence obtained from a pilot study on its effect on Influenza like illness (ILI) and molecular docking study which revealed that several compounds isolated from Ayush-64 demonstrated antiviral activity. The study aims at evaluating the effect of an Ayurvedic intervention (Ayush-64) in mild to moderate COVID-19 patients. A prospective single arm, pilot study in mild to moderate COVID-19 patients. The study was conducted at Chaudhary Brahm Prakash Ayurved Charak Sansthan (CBPACS), New Delhi, India. A total of 37 COVID-19 participants confirmed through RT-PCR were included in the study. The proportion of participants with negative SARS-CoV-2 on nasal or throat swab in a 2-day consecutive real-time RT-PCR test was evaluated as the secondary outcome. In the study, 86.1% of participants demonstrated clinical recovery with 14 days of use of Ayush-64 as stand-alone treatment without any other conventional medicines, out of which 75% clinically recovered within 8 days. Further, 69.4% of participants turned negative by the 15th day, out of which 50% became COVID-19 negative on the 8th day. No AE/ ADR was observed during the study. Ayush-64 may significantly facilitate clinical improvement in terms of duration for clinical recovery and attaining negative conversion in mild to moderate COVID-19 cases.
adult; allopathy; article; Ayurveda; clinical article; controlled study; coronavirus disease 2019; exploratory research; female; flu like syndrome; human; India; male; nonhuman; outcome assessment; prospective study; real time reverse transcription polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2; throat swab
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Traditional medicine
Language:
English
Journal:
International Journal of Research in Pharmaceutical Sciences
Year:
2022
Document Type:
Article
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