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Two Treponema pallidum strains account for the majority of syphilis infections, including among females, in Queensland, Australia.
Sweeney, Emma L; Lowry, Kym; Seel, Mandy; Rahimi, Frashta; Langton-Lockton, Julian; Bletchly, Cheryl; Nimmo, Graeme R; Whiley, David M.
  • Sweeney EL; The University of Queensland Centre for Clinical Research (UQ-CCR), Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
  • Lowry K; The University of Queensland Centre for Clinical Research (UQ-CCR), Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
  • Seel M; Metro North Public Health Unit, Brisbane, Queensland, Australia.
  • Rahimi F; The University of Queensland Centre for Clinical Research (UQ-CCR), Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
  • Langton-Lockton J; Biala Community Health Centre, Brisbane, Queensland, Australia.
  • Bletchly C; Pathology Queensland Central Laboratory, Brisbane, Queensland, Australia.
  • Nimmo GR; Pathology Queensland Central Laboratory, Brisbane, Queensland, Australia.
  • Whiley DM; Griffith University, School of Medicine, Queensland, Australia.
Commun Dis Intell (2018) ; 462022 May 19.
Article in English | MEDLINE | ID: covidwho-1856694
ABSTRACT
Abstract An ongoing outbreak of syphilis in Australia, first reported in the state of Queensland in 2011, has led to increasing cases of congenital syphilis, including several deaths. Here, we applied multi-locus sequence typing (MLST) on available Treponema pallidum PCR-positive samples from the state of Queensland from the beginning of the outbreak to July 2020. In total, 393 samples from 337 males and 56 females were genotyped. Of 36 different Treponema pallidum sequence types (ST) observed, the two most common STs, ST 1 (also reported to be a dominant strain in various other countries) and ST 100 (the latter differing from ST 1 by only one single nucleotide polymorphism (SNP) based on the MLST scheme), together comprised 69% (271/393) of all samples, including the majority of samples in females (79%; 44/56). ST 1 was prevalent throughout the entire study period. Both strains remained the most common STs during the year 2020 where social distancing and other measures were implemented due to the COVID-19 pandemic. Both STs had high male-to-female ratios and included male rectal infections, therefore suggestive of occurrence primarily among men-who-have-sex-with-men (MSM). Hence, bridging from MSM to heterosexual networks may potentially contribute to infections among females, but further studies are needed to confirm this. Overall, there was considerable diversity of Treponema pallidum genotypes observed throughout the study period, but the fact that two key strains accounted for the majority of infections, including among females, stresses the need for further investigations into the transmission of these strains, and potentially a need for targeted public health interventions to better control the spread of syphilis in Queensland.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Syphilis / Sexual and Gender Minorities / COVID-19 Type of study: Observational study Limits: Female / Humans / Male Country/Region as subject: Oceania Language: English Year: 2022 Document Type: Article Affiliation country: Cdi.2022.46.26

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Syphilis / Sexual and Gender Minorities / COVID-19 Type of study: Observational study Limits: Female / Humans / Male Country/Region as subject: Oceania Language: English Year: 2022 Document Type: Article Affiliation country: Cdi.2022.46.26