Study to estimate levels of oxidative stress biomarkers in long COVID patients
Lung India
; 39(SUPPL 1):S137-S138, 2022.
Article
in English
| EMBASE | ID: covidwho-1857128
ABSTRACT
Background:
We estimated levels of oxidative stress biomarkers (Lipid peroxidation (LPO) via Malondialdehyde MDA concentration , Superoxide dismutase (SOD), Glutathione Reductase (GR) and Total antioxidant activity (TAA) in patients who were symptomatic beyond 4 weeks of COVID infection.Methods:
It's a single centre, hospital based case control study in which levels of oxidative stress biomarkers in 40 Long COVID patients and 40 healthy controls were compared and analysed with their clinico-radiological profile.Results:
1. Lipid peroxidation (MDA) was significantly higher (1155.9 ± 204.82nmole/ml) in Long COVID patients as compared to control (715.5 ± 85.51nmole/ml) (p value 0.0405) 2. SOD in Long COVID patients was lower (18.05 ± 2.83 unit/mg) as compared to control (27.36 ± 2.18 unit/ mg) (p value 0.0096) 3. GR was reduced in Long COVID patients (10.2 ± 1.26 unit/min/mg of protein) as compared to control (15.7 ± 1.42 unit/min/mg of protein) (p value 0.0356) 4. TAA was also moderated in Long COVID patients (94.61 ± 16.40mM) as compared to control (241.64 ± 12.95mM) , (p value 0.0486) 5. LPO was directly and remaining markers were inversely proportional to the Severity of COVID and Xray Severity score 6. The patients with added comorbidities showed even higher oxidative stress than those with no comorbidities (p value 0.05) 7. Lipid peroxidation was significantly high in patients who developed neurological sequelae after COVID infection (p value 0.0083).Conclusion:
A subset of patients develop a sequelae to COVID infection and in those patients oxidative stress plays a major role.
biological marker; endogenous compound; glutathione reductase; superoxide dismutase; adult; antioxidant activity; case control study; clinical article; comorbidity; complication; conference abstract; controlled study; coronavirus disease 2019; female; human; lipid peroxidation; long COVID; male; neurological complication; oxidative stress
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Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Long Covid
Language:
English
Journal:
Lung India
Year:
2022
Document Type:
Article
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