Co-relation between computed tomography-chest and Inflammatory markers in COVID-19 patients in a tertiary care hospital in central India

ABSTRACT

Background: In December of 2019 a new corona virus was identified by WHO, secondary to an unfamiliar pneumonia in Wuhan, China, which was initially named 2019 Novel Corona Virus (2019-nCoV), and later named Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). Diagnosis was made on the basis of RT-PCR test. Methods: With use of RT-PCR as the reference standard, the performance of chest CT in the diagnosis of COVID-19 was assessed. Findings of the investigations such as HRCT, D-dimer, Sr. Ferritin, CRP, and LDH are recorded and analysed. Results: Total patients included in the study are 217 persons of which 57.89% are males, 42.10% are females. The mean age was 45.14-years. CT severity score was found to be positively correlated with increased D-dimer, LDH and S. ferritin levels. It was found that with increasing HRCT chest severity, there was increase in inflammatory marker parameters. Conclusion: Our data suggest the potential role of D-dimer, S. Ferritin and LDH for predicting severity of disease and CT scan. CT score is highly correlated to laboratory findings and might be beneficial to speed up diagnostic workup in symptomatic patients and also play a vital role in predicting the severity in places where HRCT scan is not available.