Evaluating the utility of interleukin-6, c -reactive protein (CRP) and procalcitonin in predicting disease severity and prognosis in hospitalized SARS-CoV-2 patients: a north Indian retrospective study. (Special issue.)
Arab Gulf Journal of Scientific Research
; 39(Special Issue (2):48-59, 2021.
Article
in English
| GIM | ID: covidwho-1929360
ABSTRACT
Background:
Coronavirus disease 2019 (COVID-19) associated inflammatory cytokine storm that worsens COVID-19, relies heavily on the inflammatory response. IL-6, a TH1 cytokine, PCT and CRP have been linked to serious illness and a higher mortality rate. We further tried to evaluate the role of these indicators and their association with clinical severity in COVID-19 patients. Material andMethods:
Eighty-three consecutive patients with age 18 years with RT-PCR test positive for SARS-CoV-2 were included in the study. Demographic characteristics (age and sex), underlying co-morbidities, symptoms, physical findings, and laboratory tests of the patients were recorded. All patients were categorized as having mild, moderate, and severe COVID-19 disease, according to the Indian Council of Medical Research (ICMR). The levels of IL-6 and PCT were estimated by electrochemiluminescence immunoassay (ECLIA) using Cobas-e411 Immunoassay System, and Quantitative CRP was done by Unicorn-230 automated biochemistry analyzer to find out their correlation with disease severity and outcome. Multiple Regression was performed to find out factors associated with the adverse outcome of the disease.Result:
Mean age of patients was 51 years. IL-6, CRP, and PCT levels increased in 73%, 68.0%, and 8.2% patients on admission, respectively. The most common co-morbidity associated with the disease was hypertension (25%), followed by diabetes (24%) and respiratory disease (15%). Increased IL-6, CRP, and PCT levels were found in 77 percent, 79 percent, and 20 percent of patients, respectively. We found that IL-6 (P0.05), CRP (P0.05), and PCT (P0.05) were significantly raised in COVID-19 patients with increasing severity of the disease. The Area under the receiver operating characteristic (AUROC) of these parameters ranged between 0.65 and 0.8 (IL-6, 0.828;CRP, 0.809;and PCT, 0.658), indicating a reliable biomarker to assess clinical severity.
9007-41-4; C-reactive protein; interleukin 6; human diseases; viral diseases; coronavirus disease 2019; mortality; patients; risk factors; clinical aspects; procalcitonin; automation; cytokines; hypertension; immune response; pneumonia; prognosis; symptoms; Severe acute respiratory syndrome coronavirus 2; man; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; SARS-CoV-2; viral infections; death rate; clinical picture; high blood pressure; immunity reactions; immunological reactions
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Collection:
Databases of international organizations
Database:
GIM
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Language:
English
Journal:
Arab Gulf Journal of Scientific Research
Year:
2021
Document Type:
Article
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