Diagnostic accuracy of serum ferritin, C-reactive protein, lactate dehydrogenase and D-dimer in COVID-19

ABSTRACT

Background: The Utility ofserum biomarker in the Diagnosis of COVID-19 cases has not been studied thoroughly. Aims and Objective: Tofind outthe diagnostic accuracy of serum ferritin, c-reactive protein, lactate dehydrogenase and d-dimer with RT-PCR positive moderate to severe covid-19 patients. Methods: This diagnostic accuracy study was conducted on suspected COVID-19 SARI patients and were divided into two groups based on the results of RT-PCR for COVID-19 and to minimise false-negative RT-PCR in the control group patientshaving HRCT-thorax CORADS-5 were excluded, and the accuracy of different serum biomarker in predicting cases withpositive RT-PCR was evaluated using the area under the ROC curve (AUC),In thisstudy, AUC 0.9 to 1 was defined as excellent accuracy, 0.8 to0.9 as very good, 0.7 to 0.8 as good, 0.6 to 0.7 as sufficient, 0.5to 0.6 as bad, and < 0.5 as poor(useless test). Results: 126 cases with the mean age of 47.2(range 19- 84) years were studied (73% male). The result of RT-PCR for COVID-19 waspositive in 62(49.2%) cases. Patients with positive RT-PCR had significantly higher C-reactive protein (CRP) (p = <0.001),D-dimer (p=0.001), lactate dehydrogenase (LDH) (p = <0.001) and non-significantly Serum ferritin (p=0.188).AUC of CRP(AUC=0.832), LDH (AUC=0.809), D-Dimer (AUC=0.667) and serum ferritin(AUC=0.568). Conclusion: Our findings suggest that levelsof Serum Ferritin as bad,D-DIMER as sufficient,CRPand LDH as very good biomarker to predict the results of the COVID-19 test. CRP and LDH can help in the detection of COVID-19 patients.